e-Drug3D
661
cas 55142-85-3
CLASS
BLOOD
PLATELET AGGREGATION INHIBITOR
ANTITHROMBOTIC
FIBRINOLYTIC AGENTS
P2Y PURINOCEPTOR 12 ANTAGONIST
ROUTE (list)
ORAL
ATC code
B01AC05
PK parameters
F 80 PERCENT
Tmax 2 HOUR
PPB 98 PERCENT
t1/2 108 HOUR
Solubility
FREELY SOLUBLE IN WATER
TARGET P2Y PURINOCEPTOR 12
PDB
3KW4 (CRYSTAL STRUCTURE OF CYTOCHROME 2B4 IN COMPLEX WITH THE ANTI-PLATELET DRUG TICLOPIDINE)
Ligand code = TIC (link to the list of PDB complexes)
Download experimental 3D coordinates of TIC with added hydrogens
P2Y purinoceptor 12 UNIPROT Q9H244 P2RY12
Formula:
C14H14ClNS
Calculated chemical properties:
MW 263.78
NB_atoms 17
XLogP 3.96
PSA 5.338
NB_HD 0
NB_HA 1
fsp3 0.29
Lipinski(0=no;1=yes) 1
NB_atoms 17
XLogP 3.96
PSA 5.338
NB_HD 0
NB_HA 1
fsp3 0.29
Lipinski(0=no;1=yes) 1
FDA
NDA 019979 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLID (ROCHE PALO) APPROVAL= AP YEAR= 1991 NEWMOLECULARENTITY DISCONTINUED
NDA 074994 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (NOVOPHARM LIMITED) APPROVAL= TA YEAR= 1999 OBSOLETE
NDA 075089 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075149 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (TEVA) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075161 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075253 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075316 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (NATCO PHARMA) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075318 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075326 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075309 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075526 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 019979 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLID (ROCHE PALO) APPROVAL= AP YEAR= 1991 NEWMOLECULARENTITY DISCONTINUED
NDA 074994 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (NOVOPHARM LIMITED) APPROVAL= TA YEAR= 1999 OBSOLETE
NDA 075089 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075149 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (TEVA) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075161 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075253 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075316 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (NATCO PHARMA) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075318 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075326 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075309 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075526 (pdf not found) INN (TICLOPIDINE HYDROCHLORIDE) TICLOPIDINE HYDROCHLORIDE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2002 DISCONTINUED