e-Drug3D

658

cas 86386-73-4

CLASS

ANTIINFECTIVES
ANTIFUNGAL
FUNGAL CYTOCHROME P450 DEPENDENT ENZYME LANOSTEROL 14-ALPHA-DEMETHYLASE

ROUTE (list)

ORAL INJECTION

PK parameters

F 90 PERCENT
Tmax 1.5 HOUR
VD 48.7 LITER (65 KILOGRAM)
Cl 0.9 LITER / HOUR (65 KILOGRAM)
PPB 60 PERCENT
t1/2 30 HOUR

TARGET CYTOCHROME P450 51

PDB
2WUZ (X-RAY STRUCTURE OF CYP51 FROM TRYPANOSOMA CRUZI IN COMPLEX WITH FLUCONAZOLE IN ALTERNATIVE CONFORMATION)

Ligand code = TPF (link to the list of PDB complexes)

Download experimental 3D coordinates of TPF with added hydrogens

MW 306.29
NB_atoms 22
XLogP 0.74
PSA 65.538
NB_HD 1
NB_HA 7
fsp3 0.23
Lipinski(0=no;1=yes) 1

FDA
NDA 019949 (label) INN (FLUCONAZOLE) DIFLUCAN (PFIZER) APPROVAL= AP YEAR= 1990
NDA 019950 (label) INN (FLUCONAZOLE) DIFLUCAN IN SODIUM CHLORIDE 0.9% (PFIZER) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 020090 (label) INN (FLUCONAZOLE) DIFLUCAN (PFIZER) APPROVAL= AP YEAR= 1993
NDA 076042 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (MYLAN PHARMS INC) APPROVAL= TA YEAR= 2003
NDA 076386 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (RANBAXY LABS LTD) APPROVAL= TA YEAR= 2003
NDA 076424 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (PLIVA) APPROVAL= TA YEAR= 2003
NDA 076432 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (GEDEON RICHTER USA) APPROVAL= TA YEAR= 2003
NDA 076617 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER (HOSPIRA) APPROVAL= TA YEAR= 2003
NDA 074681 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (TEVA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076077 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076086 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (ANI PHARMS) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076087 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN SODIUM CHLORIDE 0.9% (HIKMA) APPROVAL= AP YEAR= 2004
NDA 076145 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN SODIUM CHLORIDE 0.9% (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2004
NDA 076213 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (ROXANE) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076246 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (HIKMA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076303 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER (HOSPIRA) APPROVAL= AP YEAR= 2004
NDA 076304 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN DEXTROSE 5% IN PLASTIC CONTAINER (HOSPIRA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076332 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076351 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076507 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (TARO) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076653 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN SODIUM CHLORIDE 0.9% (DR REDDYS) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076658 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (DR REDDYS LABS INC) APPROVAL= AP YEAR= 2004
NDA 076665 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (CHARTWELL) APPROVAL= AP YEAR= 2004
NDA 076766 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER (BAXTER HLTHCARE) APPROVAL= AP YEAR= 2004
NDA 076736 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN SODIUM CHLORIDE 0.9% (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2005
NDA 076837 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER (DR REDDYS) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 076888 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN DEXTROSE 5% IN PLASTIC CONTAINER (PHARMOBEDIENT) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 076889 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER (MYLAN LABS LTD) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 076957 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (THINQ PHARM-CRO PVT) APPROVAL= AP YEAR= 2005
NDA 076918 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (TARO PHARM INDS) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077253 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2006
NDA 077523 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078107 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER (HIKMA) APPROVAL= AP YEAR= 2008
NDA 077731 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2008
NDA 079104 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER (INFORLIFE) APPROVAL= AP YEAR= 2009
NDA 079150 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2009
NDA 077909 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER (WOODWARD) APPROVAL= AP YEAR= 2010
NDA 077947 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN SODIUM CHLORIDE 0.9% (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 077988 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN DEXTROSE 5% IN PLASTIC CONTAINER (WOODWARD) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 078423 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (ANI PHARMS) APPROVAL= AP YEAR= 2011
NDA 078698 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2012
NDA 078764 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE IN DEXTROSE 5% IN PLASTIC CONTAINER (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 208963 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 209146 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (LUPIN LTD) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 215738 (pdf not found) INN (FLUCONAZOLE) FLUCONAZOLE (ZHEJIANG POLY PHARM) APPROVAL= AP YEAR= 2023