e-Drug3D

657

DOXACURIUM

DISCONTINUED

INN
DOXACURIUM

cas 106819-53-8

CLASS

MUSCLE RELAXANT (SKELETAL)
NEUROMUSCULAR NONDEPOLARIZING AGENTS
MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONIST

ROUTE (list)

INJECTION

ATC code

M03AC07

PK parameters

VD 14.3 LITER (65 KILOGRAM)
Cl 9.8 LITER / HOUR (65 KILOGRAM)
PPB 47 PERCENT
t1/2 1.6 HOUR

Target

TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M2
NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2

Acetylcholine receptor UNIPROT P02708 CHRNA1

Download SDF file

bis[3-[6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] butanedioate dichloride

Formula:
C56H78N2O16

Calculated chemical properties:

MW 1035.20
NB_atoms 74
XLogP 7.71
PSA 171.796
NB_HD 0
NB_HA 16
fsp3 0.54
Lipinski(0=no;1=yes) 0

FDA
NDA 019946 (label) INN (DOXACURIUM CHLORIDE) NUROMAX (ABBVIE) APPROVAL= AP YEAR= 1991 NEWMOLECULARENTITY DISCONTINUED