e-Drug3D

655

cas 58-61-7

CLASS

CARDIOVASCULAR
ANTI-ARRHYTHMIA AGENTS
VASODILATOR AGENTS
ADENOSINE PRODUCES A DIRECT NEGATIVE CHRONOTROPIC, DROMOTROPIC AND INOTROPIC EFFECT ON THE HEART

ROUTE (list)

INJECTION INTRAVENOUS

PK parameters

TARGET A1 AND A2 ADENOSINE RECEPTOR
ADENOSINE DEAMINASE
ADENOSINE KINASE

PDB
4OGR (CRYSTAL STRUCTURE OF P-TEFB COMPLEX WITH AFF4 AND TAT)

Ligand code = ADN (link to the list of PDB complexes)

Download experimental 3D coordinates of ADN with added hydrogens

MW 267.25
NB_atoms 19
XLogP -1.98
PSA 132.645
NB_HD 5
NB_HA 9
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 019937 (label) INN (ADENOSINE) ADENOCARD (ASTELLAS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 020059 (label) INN (ADENOSINE) ADENOSCAN (ASTELLAS) APPROVAL= AP YEAR= 1995 NEWAPPLICATION DISCONTINUED
NDA 076404 (pdf not found) INN (ADENOSINE) ADENOSINE (HIKMA) APPROVAL= AP YEAR= 2004
NDA 076500 (pdf not found) INN (ADENOSINE) ADENOSINE (HIKMA) APPROVAL= AP YEAR= 2004
NDA 076501 (pdf not found) INN (ADENOSINE) ADENOSINE (HIKMA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076564 (pdf not found) INN (ADENOSINE) ADENOSINE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 077133 (pdf not found) INN (ADENOSINE) ADENOSINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2005
NDA 077283 (pdf not found) INN (ADENOSINE) ADENOSINE (GLAND PHARMA LTD) APPROVAL= AP YEAR= 2007
NDA 078618 (pdf not found) INN (ADENOSINE) ADENOSINE (BEDFORD LABS) APPROVAL= TA YEAR= 2008
NDA 078676 (pdf not found) INN (ADENOSINE) ADENOSINE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078076 (pdf not found) INN (ADENOSINE) ADENOSINE (RISING) APPROVAL= AP YEAR= 2008
NDA 078686 (pdf not found) INN (ADENOSINE) ADENOSINE (MYLAN LABS LTD) APPROVAL= AP YEAR= 2009
NDA 079147 (pdf not found) INN (ADENOSINE) ADENOSINE (WOCKHARDT) APPROVAL= TA YEAR= 2009
NDA 090010 (pdf not found) INN (ADENOSINE) ADENOSINE (AM REGENT) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090220 (pdf not found) INN (ADENOSINE) ADENOSINE (WOCKHARDT) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 077425 (label) INN (ADENOSINE) ADENOSINE (MEITHEAL) APPROVAL= AP YEAR= 2013
NDA 090212 (pdf not found) INN (ADENOSINE) ADENOSINE (MYLAN ASI) APPROVAL= AP YEAR= 2014
NDA 090450 (pdf not found) INN (ADENOSINE) ADENOSINE (RISING) APPROVAL= AP YEAR= 2014
NDA 202313 (pdf not found) INN (ADENOSINE) ADENOSINE (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2014
NDA 078640 (pdf not found) INN (ADENOSINE) ADENOSINE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 203883 (pdf not found) INN (ADENOSINE) ADENOSINE (HOSPIRA) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 077897 (pdf not found) INN (ADENOSINE) ADENOSINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2017
NDA 205331 (pdf not found) INN (ADENOSINE) ADENOSINE (EUGIA PHARMA) APPROVAL= AP YEAR= 2017
NDA 205568 (pdf not found) INN (ADENOSINE) ADENOSINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2018
NDA 206778 (pdf not found) INN (ADENOSINE) ADENOSINE (GLAND) APPROVAL= AP YEAR= 2018