e-Drug3D

650

cas 303-49-1

CLASS

NERVOUS SYSTEM
ANTIDEPRESSANT
ANTIOBSESSIONAL
SEROTONIN UPTAKE INHIBITORS

ROUTE (list)

ORAL

PK parameters

Tmax 4 HOUR
VD 845 LITER (65 KILOGRAM)
Cl 31.9 LITER / HOUR (65 KILOGRAM)
PPB 97 PERCENT
t1/2 32 HOUR

TARGET SEROTONIN TRANSPORTER

PDB
4MMA (CRYSTAL STRUCTURE OF LEUBAT (DELTA13 MUTANT) IN COMPLEX WITH CLOMIPRAMINE)

Ligand code = CXX (link to the list of PDB complexes)

Download experimental 3D coordinates of CXX with added hydrogens

MW 314.84
NB_atoms 22
XLogP 4.53
PSA 7.506
NB_HD 0
NB_HA 2
fsp3 0.37
Lipinski(0=no;1=yes) 1

FDA
NDA 019906 (label) INN (CLOMIPRAMINE HYDROCHLORIDE) ANAFRANIL (SPECGX LLC) APPROVAL= AP YEAR= 1989
NDA 074364 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1996
NDA 074600 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074694 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (TARO) APPROVAL= AP YEAR= 1996
NDA 074849 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (TEVA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074953 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 1997
NDA 074958 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (TEVA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074751 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 074947 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 208961 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 208632 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (AMNEAL PHARMS CO) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 209294 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (LUPIN LTD) APPROVAL= AP YEAR= 2018
NDA 211767 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (MANKIND PHARMA) APPROVAL= AP YEAR= 2019
NDA 212218 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (JUBILANT CADISTA) APPROVAL= AP YEAR= 2019
NDA 210653 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (TRUPHARMA) APPROVAL= AP YEAR= 2020
NDA 211364 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (LEADING) APPROVAL= AP YEAR= 2020
NDA 213219 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (MICRO LABS) APPROVAL= AP YEAR= 2020
NDA 213221 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (RK PHARMA) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 212285 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (UNIQUE) APPROVAL= AP YEAR= 2020
NDA 213897 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 211822 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (ALEMBIC) APPROVAL= AP YEAR= 2021
NDA 216440 (pdf not found) INN (CLOMIPRAMINE HYDROCHLORIDE) CLOMIPRAMINE HYDROCHLORIDE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2023