e-Drug3D

64

EPINEPHRINE


INN
EPINEPHRINE

(is an active metabolite)

cas 51-43-4
CLASS

METABOLISM
ADRENERGIC AGONISTS
BRONCHODILATOR AGENTS
MYDRIATICS
SYMPATHOMIMETICS
VASOCONSTRICTOR AGENTS
EMERGENCY TREATMENT OF SEVERE ALLERGIC REACTIONS

ROUTE (list)

INJECTION INHALATION INTRAMUSCULAR SUBCUTANEOUS IONTOPHORESIS TOPICAL INTRAVENOUS INTRAOCULAR NASAL

NATURAL MOLECULE (link)

ATC code

A01AD01
B02BC09
C01CA24
R01AA14
R03AA01
S01EA01
R03AK01
S01EA51

PK parameters

t1/2 0.05 HOUR

Solubility

SOLUBLE IN WATER


Target

TARGET ALPHA ADRENERGIC RECEPTOR
BETA ADRENERGIC RECEPTOR

PDB
4LDO (STRUCTURE OF BETA2 ADRENOCEPTOR BOUND TO ADRENALINE AND AN ENGINEERED NANOBODY)

Ligand code = ALE (link to the list of PDB complexes)

Download experimental 3D coordinates of ALE with added hydrogens

DrugCentral

Beta-2 adrenergic receptor UNIPROT P07550 ADRB2

Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A

Download SDF file 4-[(1R)-1-hydroxy-2-methylaminoethyl]benzene-1,2-diol

Formula:
C9H13NO3

Calculated chemical properties:

MW 183.20
NB_atoms 13
XLogP 0.35
PSA 76.538
NB_HD 4
NB_HA 4
fsp3 0.33
Lipinski(0=no;1=yes) 1

FDA
NDA 085463 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 006488 (pdf not found) INN (EPINEPHRINE) XYLOCAINE W/ EPINEPHRINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1948
NDA 021381 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) XYLOCAINE DENTAL WITH EPINEPHRINE (DENTSPLY PHARM) APPROVAL= AP YEAR= 1948 DISCONTINUED
NDA 007942 (pdf not found) INN (EPINEPHRINE) SUS-PHRINE SULFITE FREE (FOREST LABS) APPROVAL= AP YEAR= 1951 DISCONTINUED
NDA 010374 (pdf not found) INN (EPINEPHRINE BITARTRATE) MEDIHALER-EPI (3M) APPROVAL= AP YEAR= 1956 DISCONTINUED
NDA 014763 (pdf not found) INN (EPINEPHRINE BITARTRATE ; PRILOCAINE HYDROCHLORIDE) CITANEST FORTE (ASTRAZENECA) APPROVAL= AP YEAR= 1965 NEWMOLECULARENTITY DISCONTINUED
NDA 021383 (pdf not found) INN (EPINEPHRINE BITARTRATE ; PRILOCAINE HYDROCHLORIDE) CITANEST FORTE DENTAL (DENTSPLY PHARM) APPROVAL= AP YEAR= 1965
NDA 016126 (pdf not found) INN (EPINEPHRINE) PRIMATENE MIST (WYETH CONS) APPROVAL= AP YEAR= 1967 DISCONTINUED
NDA 016803 (pdf not found) INN (EPINEPHRINE) BRONKAID MIST (STERLING) APPROVAL= AP YEAR= 1969 DISCONTINUED
NDA 010418 (pdf not found) INN (EPINEPHRINE) XYLOCAINE W/ EPINEPHRINE (ASTRAZENECA) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 016964 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) MARCAINE HYDROCHLORIDE W/ EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1972
NDA 080406 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE (WEST-WARD PHARMS INT) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080504 (pdf not found) INN (EPINEPHRINE) LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE (BELMORA LLC) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 083154 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE (ABBOTT) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080757 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE (BEL MAR) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 080758 (pdf not found) INN (EPINEPHRINE ; PROCAINE HYDROCHLORIDE) PROCAINE HYDROCHLORIDE W/ EPINEPHRINE (BEL MAR) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 080759 (pdf not found) INN (EPINEPHRINE ; PROCAINE HYDROCHLORIDE) PROCAINE HYDROCHLORIDE W/ EPINEPHRINE (BEL MAR) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 080820 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE (BEL MAR) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 080377 (pdf not found) INN (EPINEPHRINE) LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE (WATSON LABS) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 083389 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE (DELL LABS) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 083390 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE (DELL LABS) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 017751 (pdf not found) INN (EPINEPHRINE ; ETIDOCAINE HYDROCHLORIDE) DURANEST (ASTRAZENECA) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 021384 (pdf not found) INN (EPINEPHRINE BITARTRATE ; ETIDOCAINE HYDROCHLORIDE) DURANEST (DENTSPLY PHARM) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084720 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) ALPHACAINE HYDROCHLORIDE W/ EPINEPHRINE (CARLISLE) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084732 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) ALPHACAINE HYDROCHLORIDE W/ EPINEPHRINE (CARLISLE) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084048 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) OCTOCAINE (SEPTODONT) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 086402 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE (INTL MEDICATION) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 018304 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1981
NDA 022046 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1983
NDA 084728 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCATON (PHARMATON) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 084729 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCATON (PHARMATON) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 087907 (pdf not found) INN (EPINEPHRINE) EPINEPHRINE (ARMSTRONG PHARMS) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088390 (pdf not found) INN (EPINEPHRINE BITARTRATE ; LIDOCAINE HYDROCHLORIDE) LIGNOSPAN STANDARD (DEPROCO) APPROVAL= AP YEAR= 1985
NDA 088571 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1985
NDA 088389 (pdf not found) INN (EPINEPHRINE BITARTRATE ; LIDOCAINE HYDROCHLORIDE) LIGNOSPAN FORTE (DEPROCO) APPROVAL= AP YEAR= 1986
NDA 019430 (pdf not found) INN (EPINEPHRINE) EPIPEN (VIATRIS) APPROVAL= AP YEAR= 1987
NDA 070966 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1987
NDA 070967 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1987
NDA 070968 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1987
NDA 071165 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 071166 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071167 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 071168 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 071169 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071170 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 071171 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 089635 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 089644 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 089645 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 089646 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 089649 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 089650 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 089651 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 040057 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE (EASTMAN KODAK) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 020530 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) IONTOCAINE (IOMED) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 020971 (pdf not found) INN (ARTICAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) SEPTOCAINE (DEPROCO) APPROVAL= AP YEAR= 2000
NDA 020800 (pdf not found) INN (EPINEPHRINE) TWINJECT (IMPAX) APPROVAL= AP YEAR= 2003
NDA 021486 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE (EMPI) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 021504 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOSITE TOPICAL SYSTEM KIT (VYTERIS) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 022010 (pdf not found) INN (ARTICAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) SEPTOCAINE (DEPROCO) APPROVAL= AP YEAR= 2006
NDA 077250 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) VIVACAINE (SEPTODONT) APPROVAL= AP YEAR= 2006
NDA 078772 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 022466 (pdf not found) INN (ARTICAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) ORABLOC (PIERREL) APPROVAL= AP YEAR= 2010
NDA 079138 (pdf not found) INN (ARTICAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) ARTICAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATE (HOSPIRA) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 078959 (pdf not found) INN (EPINEPHRINE BITARTRATE ; PRILOCAINE HYDROCHLORIDE) PRILOCAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATE (SEPTODONT INC) APPROVAL= AP YEAR= 2011
NDA 201739 (pdf not found) INN (EPINEPHRINE) AUVI-Q (KALEO INC) APPROVAL= AP YEAR= 2012
NDA 204200 (pdf not found) INN (EPINEPHRINE) ADRENALIN (PH HEALTH) APPROVAL= AP YEAR= 2012
NDA 204640 (pdf not found) INN (EPINEPHRINE) ADRENALIN (PH HEALTH) APPROVAL= AP YEAR= 2013
NDA 205029 (pdf not found) INN (EPINEPHRINE) EPINEPHRINE (BPI LABS) APPROVAL= AP YEAR= 2014
NDA 201750 (pdf not found) INN (ARTICAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) ULTACAN FORTE (HANSAMED INC) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 201751 (pdf not found) INN (ARTICAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) ULTACAN (HANSAMED INC) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 207534 (pdf not found) INN (EPINEPHRINE) SYMJEPI (ADAMIS PHARMS CORP) APPROVAL= AP YEAR= 2017
NDA 090589 (pdf not found) INN (EPINEPHRINE) EPINEPHRINE AUTOINJECTOR (TEVA PHARMS USA) APPROVAL= AP YEAR= 2018
NDA 205920 (pdf not found) INN (EPINEPHRINE) PRIMATENE MIST (ARMSTRONG PHARMS) APPROVAL= AP YEAR= 2018
NDA 207568 (pdf not found) INN (EPINEPHRINE) EPINEPHRINE (AM REGENT) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 209359 (pdf not found) INN (EPINEPHRINE) EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 2019
NDA 211880 (pdf not found) INN (EPINEPHRINE) EPINEPHRINE (INTL MEDICATION SYS) APPROVAL= AP YEAR= 2020
NDA 208908 (pdf not found) INN (EPINEPHRINE) EPINEPHRINE (HOSPIRA INC) APPROVAL= TA YEAR= 2021
NDA 208475 (pdf not found) INN (EPINEPHRINE ; LIDOCAINE HYDROCHLORIDE) LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE (B BRAUN MEDICAL INC) APPROVAL= AP YEAR= 2021
NDA 211363 (pdf not found) INN (EPINEPHRINE) EPINEPHRINE (INTL MEDICATION SYS) APPROVAL= AP YEAR= 2022
NDA 215875 (pdf not found) INN (EPINEPHRINE) ADRENALIN (PH HEALTH) APPROVAL= AP YEAR= 2023
NDA 213708 (pdf not found) INN (EPINEPHRINE) EPINEPHRINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2024
NDA 214697 (pdf not found) INN (EPINEPHRINE) NEFFY (ARS PHARMS OPERATION) APPROVAL= AP YEAR= 2024
NDA 217192 (pdf not found) INN (EPINEPHRINE) EPINEPHRINE (AM REGENT) APPROVAL= AP YEAR= 2024
NDA 215425 (pdf not found) INN (EPINEPHRINE) EPINEPHRINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2025
NDA 218144 (pdf not found) INN (EPINEPHRINE) EPINEPHRINE (GLAND) APPROVAL= AP YEAR= 2025
NDA 218475 (pdf not found) INN (EPINEPHRINE BITARTRATE) EPINEPHRINE BITARTRATE IN 0.9% SODIUM CHLORIDE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2025
NDA 219239 (pdf not found) INN (EPINEPHRINE) EPINEPHRINE (GLAND) APPROVAL= AP YEAR= 2025

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL