e-Drug3D
632
APRACLONIDINE
INN
APRACLONIDINE
cas 66711-21-5
CLASS
SENSORY
ANTIGLAUCOMA
ALPHA ADRENERGIC ANTAGONIST
ROUTE (list)
OPHTHALMIC
ATC code
S01EA03
PK parameters
Tmax 2 HOUR
t1/2 8 HOUR
Solubility
HIGHLY SOLUBLE IN WATER
TARGET ALPHA-2A ADRENERGIC RECEPTOR
Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A
Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B
Formula:
C9H10Cl2N4
Calculated chemical properties:
MW 245.11
NB_atoms 15
XLogP 1.95
PSA 61.495
NB_HD 4
NB_HA 4
fsp3 0.22
Lipinski(0=no;1=yes) 1
NB_atoms 15
XLogP 1.95
PSA 61.495
NB_HD 4
NB_HA 4
fsp3 0.22
Lipinski(0=no;1=yes) 1
FDA
NDA 019779 (label) INN (APRACLONIDINE HYDROCHLORIDE) IOPIDINE (HARROW EYE) APPROVAL= AP YEAR= 1987
NDA 020258 (label) INN (APRACLONIDINE HYDROCHLORIDE) IOPIDINE (HARROW EYE) APPROVAL= AP YEAR= 1993
NDA 077764 (pdf not found) INN (APRACLONIDINE HYDROCHLORIDE) APRACLONIDINE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2009
NDA 019779 (label) INN (APRACLONIDINE HYDROCHLORIDE) IOPIDINE (HARROW EYE) APPROVAL= AP YEAR= 1987
NDA 020258 (label) INN (APRACLONIDINE HYDROCHLORIDE) IOPIDINE (HARROW EYE) APPROVAL= AP YEAR= 1993
NDA 077764 (pdf not found) INN (APRACLONIDINE HYDROCHLORIDE) APRACLONIDINE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2009