e-Drug3D

630

cas 19767-45-4

CLASS

VARIOUS
DETOXIFYING AGENT
DETOXIFYING AGENT TO INHIBIT THE HEMORRHAGIC CYSTITIS INDUCED BY IFOSFAMIDE
MESNA REACTS CHEMICALLY WITH THE UROTOXIC IFOSFAMIDE METABOLITES ACROLEIN AND 4-HYDROXY-IFOSFAMIDE

ROUTE (list)

INJECTION INTRAVENOUS ORAL

PK parameters

F 58 PERCENT
Tmax 2.25 HOUR
VD 42.3 LITER (65 KILOGRAM)
Cl 79.9 LITER / HOUR (65 KILOGRAM)
t1/2 0.36 HOUR

TARGET METABOLITES ACROLEIN AND 4-HYDROXY-IFOSFAMIDE

PDB
4RQX (CRYSTAL STRUCTURE OF HUMAN PEROXIREDOXIN 4(THIOREDOXIN PEROXIDASE) WITH MESNA)

Ligand code = COM (link to the list of PDB complexes)

Download experimental 3D coordinates of COM with added hydrogens

MW 142.21
NB_atoms 7
XLogP -0.20
PSA 57.092
NB_HD 1
NB_HA 3
fsp3 1.00
Lipinski(0=no;1=yes) 1

FDA
NDA 019763 (pdf not found) INN (MESNA) IFEX/MESNEX KIT (BAXTER HLTHCARE) APPROVAL= AP YEAR= 1987 NEWMOLECULARENTITY
NDA 019884 (pdf not found) INN (MESNA) MESNEX (BAXTER HLTHCARE) APPROVAL= AP YEAR= 1988
NDA 075764 (pdf not found) INN (MESNA) MESNA (TEVA PHARMS USA) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 075811 (pdf not found) INN (MESNA) MESNA (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2001
NDA 020855 (pdf not found) INN (MESNA) MESNEX (BAXTER HLTHCARE) APPROVAL= AP YEAR= 2002
NDA 075874 (pdf not found) INN (IFOSFAMIDE ; MESNA) IFOSFAMIDE/MESNA KIT (TEVA PHARMS USA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075739 (pdf not found) INN (MESNA) MESNA (HIKMA) APPROVAL= AP YEAR= 2004
NDA 090913 (pdf not found) INN (MESNA) MESNA (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2010
NDA 076488 (pdf not found) INN (MESNA) MESNA (MYLAN INSTITUTIONAL) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 203364 (pdf not found) INN (MESNA) MESNA (RISING) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 206992 (pdf not found) INN (MESNA) MESNA (GLAND) APPROVAL= AP YEAR= 2017
NDA 218871 (pdf not found) INN (MESNA) MESNA (RICONPHARMA LLC) APPROVAL= AP YEAR= 2025