e-Drug3D

629

IFOSFAMIDE

INN
IFOSFAMIDE

cas 3778-73-2

CLASS

ANTINEOPLASTIC AGENTS, ALKYLATING
ALKYLATED METABOLITES OF IFOSFAMIDE HAVE BEEN SHOWN TO INTERACT WITH DNA

ROUTE (list)

INJECTION INTRAVENOUS

ATC code

L01AA06

PK parameters

VD 40.3 LITER (65 KILOGRAM)
Cl 4.2 LITER / HOUR (65 KILOGRAM)
PPB 0 PERCENT
t1/2 6.6 HOUR

Solubility

SOLUBLE IN WATER

Target

DrugCentral

Unknown

Download SDF file

N,3-bis(2-chloroethyl)-2-oxo-1-oxa-3-aza-2(5)-phosphacyclohexan-2-amine

Formula:
C7H15Cl2N2O2P

Calculated chemical properties:

MW 261.08
NB_atoms 14
XLogP 1.88
PSA 47.198
NB_HD 1
NB_HA 4
fsp3 1.00
Lipinski(0=no;1=yes) 1

FDA
NDA 019763 (pdf not found) INN (IFOSFAMIDE) IFEX (BAXTER HLTHCARE) APPROVAL= AP YEAR= 1987
NDA 075874 (pdf not found) INN (IFOSFAMIDE ; MESNA) IFOSFAMIDE/MESNA KIT (TEVA PHARMS USA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076078 (pdf not found) INN (IFOSFAMIDE) IFOSFAMIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2002
NDA 076657 (pdf not found) INN (IFOSFAMIDE) IFOSFAMIDE (MEITHEAL) APPROVAL= AP YEAR= 2007
NDA 090181 (pdf not found) INN (IFOSFAMIDE) IFOSFAMIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 076619 (pdf not found) INN (IFOSFAMIDE) IFOSFAMIDE (HIKMA) APPROVAL= AP YEAR= 2011
NDA 201689 (pdf not found) INN (IFOSFAMIDE) IFOSFAMIDE (EXTROVIS) APPROVAL= AP YEAR= 2012 DISCONTINUED