e-Drug3D
628
CLOZAPINE
INN
CLOZAPINE
cas 5786-21-0
CLASS
NERVOUS SYSTEM
ANXIOLYTIC
ANTIPSYCHOTIC
DOPAMINE RECEPTOR ANTAGONIST
ADRENERGIC, CHOLINERGIC, HISTAMINERGIC AND SEROTONERGIC RECEPTORS ANTAGONIST
ROUTE (list)
ORAL
ATC code
N05AH02
PK parameters
Tmax 2.5 HOUR
VD 104 LITER (65 KILOGRAM)
Cl 9.7 LITER / HOUR (65 KILOGRAM)
PPB 97 PERCENT
t1/2 8 HOUR
Solubility
VERY SLIGHTLY SOLUBLE IN WATER
TARGET DOPAMINE RECEPTOR
D(2) dopamine receptor UNIPROT P14416 DRD2
5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A
Formula:
C18H19ClN4
Calculated chemical properties:
MW 326.82
NB_atoms 23
XLogP 2.03
PSA 28.359
NB_HD 1
NB_HA 4
fsp3 0.28
Lipinski(0=no;1=yes) 1
NB_atoms 23
XLogP 2.03
PSA 28.359
NB_HD 1
NB_HA 4
fsp3 0.28
Lipinski(0=no;1=yes) 1
FDA
NDA 019758 (pdf not found) INN (CLOZAPINE) CLOZARIL (HERITAGE LIFE) APPROVAL= AP YEAR= 1989
NDA 074546 (pdf not found) INN (CLOZAPINE) CLOZAPINE (SANDOZ) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074949 (pdf not found) INN (CLOZAPINE) CLOZAPINE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1997
NDA 075417 (pdf not found) INN (CLOZAPINE) CLOZAPINE (MYLAN) APPROVAL= AP YEAR= 1999
NDA 075713 (pdf not found) INN (CLOZAPINE) CLOZAPINE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021590 (pdf not found) INN (CLOZAPINE) FAZACLO ODT (JAZZ) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 075162 (pdf not found) INN (CLOZAPINE) CLOZAPINE (PAR PHARM) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 076809 (pdf not found) INN (CLOZAPINE) CLOZAPINE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2005
NDA 203479 (pdf not found) INN (CLOZAPINE) VERSACLOZ (DOUGLAS PHARMS) APPROVAL= AP YEAR= 2013
NDA 090308 (pdf not found) INN (CLOZAPINE) CLOZAPINE (BARR LABS INC) APPROVAL= AP YEAR= 2015
NDA 201824 (pdf not found) INN (CLOZAPINE) CLOZAPINE (MYLAN) APPROVAL= AP YEAR= 2015
NDA 202873 (pdf not found) INN (CLOZAPINE) CLOZAPINE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2015
NDA 203039 (pdf not found) INN (CLOZAPINE) CLOZAPINE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2015 OBSOLETE
NDA 203807 (pdf not found) INN (CLOZAPINE) CLOZAPINE (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 206433 (pdf not found) INN (CLOZAPINE) CLOZAPINE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2016
NDA 209480 (pdf not found) INN (CLOZAPINE) CLOZAPINE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 212923 (pdf not found) INN (CLOZAPINE) CLOZAPINE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2024
NDA 019758 (pdf not found) INN (CLOZAPINE) CLOZARIL (HERITAGE LIFE) APPROVAL= AP YEAR= 1989
NDA 074546 (pdf not found) INN (CLOZAPINE) CLOZAPINE (SANDOZ) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074949 (pdf not found) INN (CLOZAPINE) CLOZAPINE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1997
NDA 075417 (pdf not found) INN (CLOZAPINE) CLOZAPINE (MYLAN) APPROVAL= AP YEAR= 1999
NDA 075713 (pdf not found) INN (CLOZAPINE) CLOZAPINE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021590 (pdf not found) INN (CLOZAPINE) FAZACLO ODT (JAZZ) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 075162 (pdf not found) INN (CLOZAPINE) CLOZAPINE (PAR PHARM) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 076809 (pdf not found) INN (CLOZAPINE) CLOZAPINE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2005
NDA 203479 (pdf not found) INN (CLOZAPINE) VERSACLOZ (DOUGLAS PHARMS) APPROVAL= AP YEAR= 2013
NDA 090308 (pdf not found) INN (CLOZAPINE) CLOZAPINE (BARR LABS INC) APPROVAL= AP YEAR= 2015
NDA 201824 (pdf not found) INN (CLOZAPINE) CLOZAPINE (MYLAN) APPROVAL= AP YEAR= 2015
NDA 202873 (pdf not found) INN (CLOZAPINE) CLOZAPINE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2015
NDA 203039 (pdf not found) INN (CLOZAPINE) CLOZAPINE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2015 OBSOLETE
NDA 203807 (pdf not found) INN (CLOZAPINE) CLOZAPINE (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 206433 (pdf not found) INN (CLOZAPINE) CLOZAPINE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2016
NDA 209480 (pdf not found) INN (CLOZAPINE) CLOZAPINE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 212923 (pdf not found) INN (CLOZAPINE) CLOZAPINE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2024