e-Drug3D

626

cas 82419-36-1

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
DNA TOPOISOMERASE IV INHIBITOR
DNA GYRASE INHIBITOR
QUINOLONES

ROUTE (list)

ORAL OPHTHALMIC INJECTION OTIC

PK parameters

F 98 PERCENT
Tmax 1.5 HOUR
VD 104 LITER (65 KILOGRAM)
Cl 9.7 LITER / HOUR (65 KILOGRAM)
PPB 32 PERCENT
t1/2 4.5 HOUR (ONE DOSE)

TARGET DNA TOPOISOMERASE 4
DNA GYRASE

PDB
2BML (OFLOXACIN-LIKE ANTIBIOTICS INHIBIT PNEUMOCOCCAL CELL WALL DEGRADING VIRULENCE FACTORS)

Ligand code = XED (link to the list of PDB complexes)

Download experimental 3D coordinates of XED with added hydrogens

MW 360.36
NB_atoms 26
XLogP 0.21
PSA 75.296
NB_HD 0
NB_HA 7
fsp3 0.44
Lipinski(0=no;1=yes) 1

FDA
NDA 019735 (pdf not found) INN (OFLOXACIN) FLOXIN (JANSSEN PHARMS) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 020087 (pdf not found) INN (OFLOXACIN) FLOXIN IN DEXTROSE 5% (ORTHO MCNEIL PHARM) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 019921 (pdf not found) INN (OFLOXACIN) OCUFLOX (ALLERGAN) APPROVAL= AP YEAR= 1993
NDA 020799 (pdf not found) INN (OFLOXACIN) FLOXIN OTIC (DAIICHI) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 075762 (pdf not found) INN (OFLOXACIN) OFLOXACIN (BEDFORD) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076093 (pdf not found) INN (OFLOXACIN) OFLOXACIN (CHARTWELL RX) APPROVAL= AP YEAR= 2003
NDA 076182 (pdf not found) INN (OFLOXACIN) OFLOXACIN (TEVA) APPROVAL= AP YEAR= 2003
NDA 076220 (pdf not found) INN (OFLOXACIN) OFLOXACIN (RANBAXY LABS LTD) APPROVAL= TA YEAR= 2003
NDA 076231 (pdf not found) INN (OFLOXACIN) OFLOXACIN (SANDOZ) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076513 (pdf not found) INN (OFLOXACIN) OFLOXACIN (APOTEX INC) APPROVAL= AP YEAR= 2004
NDA 076615 (pdf not found) INN (OFLOXACIN) OFLOXACIN (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076622 (pdf not found) INN (OFLOXACIN) OFLOXACIN (BAUSCH AND LOMB) APPROVAL= AP YEAR= 2004
NDA 076830 (pdf not found) INN (OFLOXACIN) OFLOXACIN (ALVOGEN) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 077098 (pdf not found) INN (OFLOXACIN) OFLOXACIN (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2006
NDA 076527 (pdf not found) INN (OFLOXACIN) OFLOXACIN (APOTEX INC) APPROVAL= AP YEAR= 2007
NDA 076128 (pdf not found) INN (OFLOXACIN) OFLOXACIN (BAUSCH AND LOMB) APPROVAL= AP YEAR= 2008
NDA 076407 (pdf not found) INN (OFLOXACIN) OFLOXACIN (SENTISS) APPROVAL= AP YEAR= 2008
NDA 076616 (pdf not found) INN (OFLOXACIN) OFLOXACIN (HIKMA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078222 (pdf not found) INN (OFLOXACIN) OFLOXACIN (SANDOZ) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 076848 (pdf not found) INN (OFLOXACIN) OFLOXACIN (SANDOZ) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078559 (pdf not found) INN (OFLOXACIN) OFLOXACIN (FDC LTD) APPROVAL= AP YEAR= 2009
NDA 090395 (pdf not found) INN (OFLOXACIN) OFLOXACIN (ALVOGEN) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 202692 (pdf not found) INN (OFLOXACIN) OFLOXACIN (ALTAIRE PHARMS INC) APPROVAL= AP YEAR= 2013
NDA 091656 (pdf not found) INN (OFLOXACIN) OFLOXACIN (CADILA PHARMS LTD) APPROVAL= AP YEAR= 2014
NDA 211525 (pdf not found) INN (OFLOXACIN) OFLOXACIN (AMNEAL) APPROVAL= AP YEAR= 2019
NDA 215038 (pdf not found) INN (OFLOXACIN) OFLOXACIN (FDC LTD) APPROVAL= AP YEAR= 2022
NDA 215886 (pdf not found) INN (OFLOXACIN) OFLOXACIN (MANKIND PHARMA) APPROVAL= AP YEAR= 2022
NDA 216130 (pdf not found) INN (OFLOXACIN) OFLOXACIN (MANKIND PHARMA) APPROVAL= AP YEAR= 2022
NDA 211524 (pdf not found) INN (OFLOXACIN) OFLOXACIN (AMNEAL) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 217903 (pdf not found) INN (OFLOXACIN) OFLOXACIN (CAPLIN) APPROVAL= AP YEAR= 2024
NDA 217904 (pdf not found) INN (OFLOXACIN) OFLOXACIN (CAPLIN) APPROVAL= AP YEAR= 2024
NDA 213597 (pdf not found) INN (OFLOXACIN) OFLOXACIN (SOMERSET) APPROVAL= AP YEAR= 2024
NDA 216328 (pdf not found) INN (OFLOXACIN) OFLOXACIN (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2024