e-Drug3D
623
cas 82410-32-0
CLASS
ANTIINFECTIVES
ANTIVIRAL
CYTOMEGALOVIRUS (CMV)
HERPES SIMPLEX VIRUS (HSV)
ACYCLIC NUCLEOSIDE ANALOGUE OF 2'-DEOXYGUANOSINE
ROUTE (list)
INJECTION ORAL IMPLANTATION OPHTHALMIC INTRAVENOUS
PK parameters
Tmax 2 HOUR
VD 45.7 LITER (65 KILOGRAM)
Cl 11.9 LITER / HOUR
PPB 1 PERCENT
t1/2 3.81 HOUR
Solubility
APPROXIMATELY 6 MILLIGRAM / MILLILITER AT 37 DEGREE CELSIUS
TARGET THYMIDINE KINASE
PDB
1KI2 (THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I)
Ligand code = GA2 (link to the list of PDB complexes)
Download experimental 3D coordinates of GA2 with added hydrogens
DNA polymerase catalytic subunit UNIPROT P04293
Formula:
C9H13N5O4
Calculated chemical properties:
MW 255.24
NB_atoms 18
XLogP -1.97
PSA 128.967
NB_HD 5
NB_HA 9
fsp3 0.44
Lipinski(0=no;1=yes) 1
NB_atoms 18
XLogP -1.97
PSA 128.967
NB_HD 5
NB_HA 9
fsp3 0.44
Lipinski(0=no;1=yes) 1
FDA
NDA 076457 (pdf not found) INN (GANCICLOVIR) GANCICLOVIR (RANBAXY LABS LTD) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 019661 (pdf not found) INN (GANCICLOVIR SODIUM) CYTOVENE (CHEPLAPHARM) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 020460 (pdf not found) INN (GANCICLOVIR) CYTOVENE (ROCHE PALO) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 020569 (pdf not found) INN (GANCICLOVIR) VITRASERT (BAUSCH AND LOMB) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 076222 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (HIKMA) APPROVAL= AP YEAR= 2003
NDA 022211 (pdf not found) INN (GANCICLOVIR) ZIRGAN (BAUSCH AND LOMB) APPROVAL= AP YEAR= 2009
NDA 090658 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2010
NDA 202624 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (AM REGENT) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 204950 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (PH HEALTH) APPROVAL= AP YEAR= 2016
NDA 209347 (pdf not found) INN (GANCICLOVIR) GANZYK-RTU (EXELA PHARMA) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 204560 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 207645 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (PHARMASCIENCE INC) APPROVAL= AP YEAR= 2017
NDA 204204 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (SLATE RUN PHARMA) APPROVAL= AP YEAR= 2018
NDA 212001 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (CUSTOPHARM INC) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 076457 (pdf not found) INN (GANCICLOVIR) GANCICLOVIR (RANBAXY LABS LTD) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 019661 (pdf not found) INN (GANCICLOVIR SODIUM) CYTOVENE (CHEPLAPHARM) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 020460 (pdf not found) INN (GANCICLOVIR) CYTOVENE (ROCHE PALO) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 020569 (pdf not found) INN (GANCICLOVIR) VITRASERT (BAUSCH AND LOMB) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 076222 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (HIKMA) APPROVAL= AP YEAR= 2003
NDA 022211 (pdf not found) INN (GANCICLOVIR) ZIRGAN (BAUSCH AND LOMB) APPROVAL= AP YEAR= 2009
NDA 090658 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2010
NDA 202624 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (AM REGENT) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 204950 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (PH HEALTH) APPROVAL= AP YEAR= 2016
NDA 209347 (pdf not found) INN (GANCICLOVIR) GANZYK-RTU (EXELA PHARMA) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 204560 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 207645 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (PHARMASCIENCE INC) APPROVAL= AP YEAR= 2017
NDA 204204 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (SLATE RUN PHARMA) APPROVAL= AP YEAR= 2018
NDA 212001 (pdf not found) INN (GANCICLOVIR SODIUM) GANCICLOVIR SODIUM (CUSTOPHARM INC) APPROVAL= AP YEAR= 2019 DISCONTINUED