e-Drug3D

616

cas 75330-75-5

CLASS

CARDIOVASCULAR
HYPOLIPIDEMIC
ANTICHOLESTEREMIC AGENTS
HYDROXYMETHYLGLUTARYL-COA (HMG-COA) REDUCTASE INHIBITORS

ROUTE (list)

ORAL

PK parameters

F 30 PERCENT
Tmax 2 HOUR
PPB 95 PERCENT
t1/2 4.5 HOUR

TARGET 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE

PDB
1CQP (CRYSTAL STRUCTURE ANALYSIS OF THE COMPLEX LFA-1 (CD11A) I-DOMAIN, LOVASTATIN AT 2.6 A RESOLUTION)

Ligand code = 803 (link to the list of PDB complexes)

Download experimental 3D coordinates of 803 with added hydrogens

MW 404.53
NB_atoms 29
XLogP 4.20
PSA 67.515
NB_HD 1
NB_HA 5
fsp3 0.75
Lipinski(0=no;1=yes) 1

FDA
NDA 019643 (label) INN (LOVASTATIN) MEVACOR (MERCK) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 021249 (label) INN (LOVASTATIN) ADVICOR (ABBVIE) APPROVAL= AP YEAR= 2001 OBSOLETE
NDA 075300 (pdf not found) INN (LOVASTATIN) LOVASTATIN (CHARTWELL RX) APPROVAL= AP YEAR= 2001
NDA 075451 (pdf not found) INN (LOVASTATIN) LOVASTATIN (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 075551 (pdf not found) INN (LOVASTATIN) LOVASTATIN (TEVA) APPROVAL= AP YEAR= 2001
NDA 075636 (pdf not found) INN (LOVASTATIN) LOVASTATIN (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2001
NDA 075828 (pdf not found) INN (LOVASTATIN) LOVASTATIN (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2001
NDA 075935 (pdf not found) INN (LOVASTATIN) LOVASTATIN (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 021316 (label) INN (LOVASTATIN) ALTOPREV (COVIS) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075991 (pdf not found) INN (LOVASTATIN) LOVASTATIN (CARLSBAD) APPROVAL= AP YEAR= 2002
NDA 077520 (pdf not found) INN (LOVASTATIN) LOVASTATIN (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077748 (pdf not found) INN (LOVASTATIN) LOVASTATIN (COREPHARMA) APPROVAL= AP YEAR= 2007
NDA 078296 (pdf not found) INN (LOVASTATIN) LOVASTATIN (LUPIN) APPROVAL= AP YEAR= 2007