e-Drug3D

615

PROPOFOL

INN
PROPOFOL

(is an active metabolite)

cas 2078-54-8

CLASS

NERVOUS SYSTEM
ANESTHETIC
ANTICONVULSANTS
ANTIEMETICS
FREE RADICAL SCAVENGERS
HYPNOTICS
SEDATIVES
GABA-A AGONIST

ROUTE (list)

INJECTION

ATC code

N01AX10

PK parameters

VD 305 LITER (65 KILOGRAM)
Cl 150 LITER / HOUR
PPB 98 PERCENT
t1/2 3.2 HOUR

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABA(A))
BETA-ADRENOCEPTOR (BETA-AR) (PMID21793316)

PDB
5MVN (X-RAY STRUCTURE OF THE M205W MUTANT OF GLIC IN COMPLEX WITH PROPOFOL)

Ligand code = PFL (link to the list of PDB complexes)

Download experimental 3D coordinates of PFL with added hydrogens

DrugCentral

GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1

GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1

Download SDF file

2,6-di(propan-2-yl)phenol

Formula:
C12H18O

Calculated chemical properties:

MW 178.26
NB_atoms 13
XLogP 3.64
PSA 19.038
NB_HD 1
NB_HA 1
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 019627 (pdf not found) INN (PROPOFOL) DIPRIVAN (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1989
NDA 074704 (pdf not found) INN (PROPOFOL) PROPOFOL (ABBOTT) APPROVAL= TA YEAR= 1997 OBSOLETE
NDA 074719 (pdf not found) INN (PROPOFOL) PROPOFOL (BAXTER HLTHCARE) APPROVAL= TA YEAR= 1998
NDA 074816 (pdf not found) INN (PROPOFOL) PROPOFOL (GENSIA SICOR PHARMS) APPROVAL= TA YEAR= 1998
NDA 075040 (pdf not found) INN (PROPOFOL) PROPOFOL (ESI LEDERLE) APPROVAL= TA YEAR= 1999
NDA 075102 (pdf not found) INN (PROPOFOL) PROPOFOL (SAGENT PHARMS INC) APPROVAL= AP YEAR= 1999
NDA 075392 (pdf not found) INN (PROPOFOL) PROPOFOL (TEVA PARENTERAL) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 074848 (pdf not found) INN (PROPOFOL) PROPOFOL (HIKMA) APPROVAL= AP YEAR= 2005
NDA 077908 (pdf not found) INN (PROPOFOL) PROPOFOL (HOSPIRA) APPROVAL= AP YEAR= 2006
NDA 205307 (pdf not found) INN (PROPOFOL) PROPOFOL (WATSON LABS INC) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 205067 (pdf not found) INN (PROPOFOL) PROPOFOL (DR REDDYS) APPROVAL= AP YEAR= 2018
NDA 205576 (pdf not found) INN (PROPOFOL) PROPOFOL (INNOPHARMA) APPROVAL= AP YEAR= 2020
NDA 206408 (pdf not found) INN (PROPOFOL) PROPOFOL (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2021
NDA 217013 (pdf not found) INN (PROPOFOL) PROPOFOL (ASPIRO) APPROVAL= AP YEAR= 2024
NDA 217525 (pdf not found) INN (PROPOFOL) PROPOFOL (AMNEAL) APPROVAL= AP YEAR= 2024