e-Drug3D

614

ENOXACIN

DISCONTINUED

INN
ENOXACIN

cas 74011-58-8

CLASS

ANTIINFECTIVES
BROAD-SPECTRUM AZAFLUOROQUINOLONE ANTIBIOTIC
ANTIBACTERIAL

ROUTE (list)

ORAL

ATC code

J01MA04

PK parameters

F 90 PERCENT
Tmax 2 HOUR
VD 130 LITER (65 KILOGRAM)
Cl 21 LITER / HOUR (65 KILOGRAM)
PPB 40 PERCENT
t1/2 4.5 HOUR

Target

TARGET DNA GYRASE

Topoisomerase IV UNIPROT P48374 parC

DNA gyrase UNIPROT P22118 gyrB

Download SDF file

1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,8-naphthyridine-3-carboxylic acid

Formula:
C15H17FN4O3

Calculated chemical properties:

MW 319.32
NB_atoms 23
XLogP -0.67
PSA 80.322
NB_HD 1
NB_HA 7
fsp3 0.40
Lipinski(0=no;1=yes) 1

FDA
NDA 019616 (pdf not found) INN (ENOXACIN) PENETREX (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1991 NEWMOLECULARENTITY DISCONTINUED