e-Drug3D

610

TERCONAZOLE


INN
TERCONAZOLE

cas 67915-31-5
CLASS

GENITO
ANTIFUNGAL (CANDIDA ALBICANS)
TREATMENT OF VULVOVAGINAL CANDIDIASIS
NHIBITION OF ERGOSTEROL SYNTHESIS AND DISRUPTION OF NORMAL FUNGAL CELL MEMBRANE PERMEABILITY

ROUTE (list)

VAGINAL

ATC code

G01AG02

PK parameters

F 16 PERCENT
Tmax 6.6 HOUR
PPB 94.9 PERCENT
t1/2 6.9 HOUR

Solubility

INSOLUBLE IN WATER


Target

TARGET CYTOCHROME P450 14 ALPHA-DEMETHYLASE

DrugCentral

Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11

Download SDF file 1-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-propan-2-ylpiperazine

Formula:
C26H31Cl2N5O3

Calculated chemical properties:

MW 532.46
NB_atoms 36
XLogP 4.46
PSA 66.946
NB_HD 0
NB_HA 8
fsp3 0.46
Lipinski(0=no;1=yes) 0

FDA
NDA 019579 (pdf not found) INN (TERCONAZOLE) TERAZOL 7 (JANSSEN PHARMS) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 019641 (pdf not found) INN (TERCONAZOLE) TERAZOL 3 (JANSSEN PHARMS) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 019964 (pdf not found) INN (TERCONAZOLE) TERAZOL 3 (JANSSEN PHARMS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 021735 (pdf not found) INN (TERCONAZOLE) TERCONAZOLE (FOUGERA PHARMS INC) APPROVAL= AP YEAR= 2004
NDA 075953 (pdf not found) INN (TERCONAZOLE) TERCONAZOLE (TARO) APPROVAL= AP YEAR= 2004
NDA 076043 (pdf not found) INN (TERCONAZOLE) TERCONAZOLE (TARO) APPROVAL= AP YEAR= 2005
NDA 076712 (pdf not found) INN (TERCONAZOLE) TERCONAZOLE (FOUGERA PHARMS) APPROVAL= AP YEAR= 2005
NDA 076850 (pdf not found) INN (TERCONAZOLE) TERCONAZOLE (FOUGERA PHARMS) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077149 (pdf not found) INN (TERCONAZOLE) TERCONAZOLE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2006
NDA 077553 (pdf not found) INN (TERCONAZOLE) TERCONAZOLE (TARO) APPROVAL= AP YEAR= 2007

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL