e-Drug3D

598

PINACIDIL

DISCONTINUED

INN
PINACIDIL

cas 60560-33-0

CLASS

CARDIOVASCULAR
ATP-DEPENDENT POTASSIUM CHANNEL AGONIST
ANTIHYPERTENSIVE

ROUTE (list)

ORAL

PK parameters

F 57 PERCENT
VD 91 LITER (65 KILOGRAM) (PMID4007251)
Cl 31.5 LITER / HOUR (EQN)
t1/2 2 HOUR (PMID4007251)

Target

TARGET ATP-DEPENDENT POTASSIUM CHANNEL

Sulfonylurea receptor 2, Kir6.2 UNIPROT O60706 ABCC9

Download SDF file

Guanidine, N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-

Formula:
C13H19N5

Calculated chemical properties:

MW 245.33
NB_atoms 18
XLogP 2.35
PSA 58.453
NB_HD 2
NB_HA 5
fsp3 0.46
Lipinski(0=no;1=yes) 1

FDA
NDA 019456 (pdf not found) INN (PINACIDIL) PINDAC (LEO PHARM) APPROVAL= AP YEAR= 1989 NEWMOLECULARENTITY DISCONTINUED