e-Drug3D

583

cas 65271-80-9

CLASS

ANTINEOPLASTIC
INTERCALATING AGENT

ROUTE (list)

INJECTION

PK parameters

VD 1610 LITER
Cl 30.8 LITER / HOUR
PPB 78 PERCENT
t1/2 53 HOUR

TARGET DNA
DNA TOPOISOMERASE 2

PDB
2KGP (STRUCTURAL BASIS FOR STABILIZATION OF THE TAU PRE-MRNA SPLICING REGULATORY ELEMENT BY NOVANTRONE (MITOXANTRONE))

Ligand code = MIX (link to the list of PDB complexes)

Download experimental 3D coordinates of MIX with added hydrogens

MW 444.48
NB_atoms 32
XLogP -0.14
PSA 160.308
NB_HD 8
NB_HA 10
fsp3 0.36
Lipinski(0=no;1=yes) 0

FDA
NDA 019297 (pdf not found) INN (MITOXANTRONE HYDROCHLORIDE) NOVANTRONE (EMD SERONO) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 021120 (pdf not found) INN (MITOXANTRONE HYDROCHLORIDE) NOVANTRONE (SERONO INC) APPROVAL= AP YEAR= 2000 NEWAPPLICATION DISCONTINUED
NDA 076611 (pdf not found) INN (MITOXANTRONE HYDROCHLORIDE) MITOXANTRONE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2006
NDA 076871 (pdf not found) INN (MITOXANTRONE HYDROCHLORIDE) MITOXANTRONE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 2006
NDA 077356 (pdf not found) INN (MITOXANTRONE HYDROCHLORIDE) MITOXANTRONE HYDROCHLORIDE (MEITHEAL) APPROVAL= AP YEAR= 2006
NDA 077496 (pdf not found) INN (MITOXANTRONE HYDROCHLORIDE) MITOXANTRONE HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2006
NDA 078606 (pdf not found) INN (MITOXANTRONE HYDROCHLORIDE) MITOXANTRONE HYDROCHLORIDE (FRESENIUS KABI ONCOL) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078980 (pdf not found) INN (MITOXANTRONE HYDROCHLORIDE) MITOXANTRONE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 201014 (pdf not found) INN (MITOXANTRONE HYDROCHLORIDE) MITOXANTRONE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2012 DISCONTINUED