e-Drug3D

582

cas 1197-18-8

CLASS

BLOOD
HEMOSTATIC
ANTIFIBRINOLYTIC
TREATMENT OF CYCLIC HEAVY MENSTRUAL BLEEDING
COMPETITIVE INHIBITOR OF PLASMINOGEN ACTIVATION

ROUTE (list)

ORAL INJECTION INTRAVENOUS

PK parameters

F 45 PERCENT
Tmax 3 HOUR
VD 25.3 LITER (65 KILOGRAM)
Cl 6.7 LITER / HOUR
PPB 3 PERCENT
t1/2 11 HOUR

TARGET PLASMINOGEN

PDB
1B2I (KRINGLE 2 DOMAIN OF HUMAN PLASMINOGEN: NMR SOLUTION STRUCTURE OF TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID (AMCHA) COMPLEX)

Ligand code = AMH (link to the list of PDB complexes)

Download experimental 3D coordinates of AMH with added hydrogens

MW 156.20
NB_atoms 11
XLogP -0.50
PSA 59.786
NB_HD 2
NB_HA 3
fsp3 0.88
Lipinski(0=no;1=yes) 1

FDA
NDA 019280 (pdf not found) INN (TRANEXAMIC ACID) CYKLOKAPRON (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1986 NEWMOLECULARENTITY DISCONTINUED
NDA 019281 (pdf not found) INN (TRANEXAMIC ACID) CYKLOKAPRON (PFIZER) APPROVAL= AP YEAR= 1986
NDA 022430 (pdf not found) INN (TRANEXAMIC ACID) LYSTEDA (AMRING PHARMS) APPROVAL= AP YEAR= 2009
NDA 091657 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (MYLAN INSTITUTIONAL) APPROVAL= AP YEAR= 2011
NDA 201885 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (AM REGENT) APPROVAL= AP YEAR= 2011
NDA 202373 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2011
NDA 091596 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202093 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 2012
NDA 201580 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (XGEN PHARMS) APPROVAL= AP YEAR= 2013
NDA 202286 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (APOTEX) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 202436 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (HERITAGE) APPROVAL= AP YEAR= 2014
NDA 203521 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2014
NDA 205133 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 2015
NDA 202755 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (CHARTWELL RX) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 205035 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (EUGIA PHARMA) APPROVAL= AP YEAR= 2016
NDA 206634 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (RISING) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 203256 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (ANI PHARMS) APPROVAL= AP YEAR= 2016
NDA 205228 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 206713 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (MICRO LABS) APPROVAL= AP YEAR= 2017
NDA 207239 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (GLAND) APPROVAL= AP YEAR= 2017
NDA 208840 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (AMNEAL PHARMS CO) APPROVAL= AP YEAR= 2017
NDA 206594 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 209326 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (ACIC PHARMS) APPROVAL= AP YEAR= 2019 OBSOLETE
NDA 212020 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (EXELA PHARMA) APPROVAL= AP YEAR= 2019
NDA 212360 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (CAPLIN) APPROVAL= AP YEAR= 2019
NDA 212676 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (PROVEPHARM SAS) APPROVAL= AP YEAR= 2019
NDA 209860 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (APOTEX) APPROVAL= AP YEAR= 2020
NDA 217155 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (AMNEAL) APPROVAL= AP YEAR= 2023
NDA 216877 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (NEXUS) APPROVAL= AP YEAR= 2024
NDA 218320 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (RUBICON RESEARCH) APPROVAL= AP YEAR= 2024
NDA 218599 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (GLAND) APPROVAL= AP YEAR= 2024
NDA 218242 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2024
NDA 218729 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (APPCO) APPROVAL= AP YEAR= 2025
NDA 218896 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (RTU PHARMA SA) APPROVAL= AP YEAR= 2025
NDA 219123 (pdf not found) INN (TRANEXAMIC ACID) TRANEXAMIC ACID (BIONPHARMA) APPROVAL= AP YEAR= 2025