e-Drug3D

581

cas 63659-18-7

CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE
ANTIANGINAL
ADRENERGIC BETA ANTAGONISTS
EENT DRUGS
SYMPATHOLYTICS
INTRAOCULAR PRESSURE AND IS INDICATED IN THE TREATMENT OF OCULAR HYPERTENSION AND CHRONIC OPEN-ANGLE GLAUCOMA.

ROUTE (list)

OPHTHALMIC ORAL

PK parameters

F 89 PERCENT
Tmax 3 HOUR
VD 312 LITER (65 KILOGRAM)
Cl 13.26 LITER / HOUR (65 KILOGRAM)
PPB 50 PERCENT
t1/2 18 HOUR

MW 307.42
NB_atoms 22
XLogP 2.39
PSA 56.068
NB_HD 2
NB_HA 4
fsp3 0.67
Lipinski(0=no;1=yes) 1

FDA
NDA 019270 (label) INN (BETAXOLOL HYDROCHLORIDE) BETOPTIC (ALCON) APPROVAL= AP YEAR= 1985 NEWMOLECULARENTITY
NDA 019507 (label) INN (BETAXOLOL HYDROCHLORIDE) KERLONE (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 019845 (label) INN (BETAXOLOL HYDROCHLORIDE) BETOPTIC S (ALCON) APPROVAL= AP YEAR= 1989
NDA 019807 (label) INN (BETAXOLOL HYDROCHLORIDE) KERLEDEX (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 020619 (pdf not found) INN (BETAXOLOL HYDROCHLORIDE) BETOPTIC PILO (ALCON) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 075541 (label) INN (BETAXOLOL HYDROCHLORIDE) BETAXOLOL HYDROCHLORIDE (EPIC PHARMA) APPROVAL= AP YEAR= 1999
NDA 075386 (pdf not found) INN (BETAXOLOL HYDROCHLORIDE) BETAXOLOL HYDROCHLORIDE (AKORN) APPROVAL= AP YEAR= 2000
NDA 075446 (pdf not found) INN (BETAXOLOL HYDROCHLORIDE) BETAXOLOL HYDROCHLORIDE (NOVEX) APPROVAL= AP YEAR= 2000
NDA 075630 (pdf not found) INN (BETAXOLOL HYDROCHLORIDE) BETAXOLOL HYDROCHLORIDE (BAUSCH AND LOMB) APPROVAL= AP YEAR= 2000
NDA 021114 (label) INN (LEVOBETAXOLOL HYDROCHLORIDE) BETAXON (ALCON PHARMS LTD) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 078962 (pdf not found) INN (BETAXOLOL HYDROCHLORIDE) BETAXOLOL HYDROCHLORIDE (KVK TECH) APPROVAL= AP YEAR= 2008
NDA 078694 (pdf not found) INN (BETAXOLOL HYDROCHLORIDE) BETAXOLOL HYDROCHLORIDE (WOCKHARDT) APPROVAL= AP YEAR= 2009