e-Drug3D
573
PROPAFENONE
INN
PROPAFENONE
cas 54063-53-5
CLASS
CARDIOVASCULAR
CLASS 1C ANTIARRHYTHMIC
CHANNEL BLOCKER
ROUTE (list)
ORAL
ATC code
C01BC03
PK parameters
F 12 PERCENT
Tmax 3.5 HOUR
VD 252 LITER
Cl 57 LITER / HOUR
PPB 95 PERCENT
t1/2 21 HOUR
Solubility
SLIGHTLY SOLUBLE IN WATER
TARGET POTASSIUM VOLTAGE-GATED CHANNEL
SODIUM CHANNEL
Beta-1 adrenergic receptor UNIPROT P08588 ADRB1
Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A
Formula:
C21H27NO3
Calculated chemical properties:
MW 341.44
NB_atoms 25
XLogP 3.24
PSA 59.082
NB_HD 2
NB_HA 4
fsp3 0.38
Lipinski(0=no;1=yes) 1
NB_atoms 25
XLogP 3.24
PSA 59.082
NB_HD 2
NB_HA 4
fsp3 0.38
Lipinski(0=no;1=yes) 1
FDA
NDA 019151 (label) INN (PROPAFENONE HYDROCHLORIDE) RYTHMOL (GLAXOSMITHKLINE LLC) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 075203 (label) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 2000
NDA 075998 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 075938 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 2002
NDA 076193 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (NESHER PHARMS) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021416 (label) INN (PROPAFENONE HYDROCHLORIDE) RYTHMOL SR (GLAXOSMITHKLINE LLC) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076550 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 2004
NDA 078540 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 2010
NDA 202688 (label) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (WATSON LABS INC) APPROVAL= AP YEAR= 2015
NDA 202445 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2016
NDA 203803 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 205268 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2017
NDA 205956 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2018
NDA 210339 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (SINOTHERAPEUTICS INC) APPROVAL= AP YEAR= 2019
NDA 212744 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2020
NDA 212928 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (TWI PHARMS) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 214184 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2021
NDA 213096 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2023
NDA 019151 (label) INN (PROPAFENONE HYDROCHLORIDE) RYTHMOL (GLAXOSMITHKLINE LLC) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 075203 (label) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 2000
NDA 075998 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 075938 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 2002
NDA 076193 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (NESHER PHARMS) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021416 (label) INN (PROPAFENONE HYDROCHLORIDE) RYTHMOL SR (GLAXOSMITHKLINE LLC) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076550 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 2004
NDA 078540 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 2010
NDA 202688 (label) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (WATSON LABS INC) APPROVAL= AP YEAR= 2015
NDA 202445 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2016
NDA 203803 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 205268 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2017
NDA 205956 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2018
NDA 210339 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (SINOTHERAPEUTICS INC) APPROVAL= AP YEAR= 2019
NDA 212744 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2020
NDA 212928 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (TWI PHARMS) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 214184 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2021
NDA 213096 (pdf not found) INN (PROPAFENONE HYDROCHLORIDE) PROPAFENONE HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2023