e-Drug3D
570
ESTAZOLAM
INN
ESTAZOLAM
cas 29975-16-4
CLASS
NERVOUS SYSTEM
HYPNOTIC
ANXIOLYTIC
MANAGEMENT OF INSOMNIA
GABA MODULATORS
BENZODIAZEPINE
ROUTE (list)
ORAL
ATC code
N05CD04
PK parameters
Tmax 2 HOUR
PPB 93 PERCENT
t1/2 17 HOUR
Solubility
PRACTICALLY INSOLUBLE IN WATER
TARGET GABA RECEPTOR
GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1
GABA-A receptor alpha-2,beta-3,gamma-2 UNIPROT P18507 GABRG2
Formula:
C16H11ClN4
Calculated chemical properties:
MW 294.74
NB_atoms 21
XLogP 3.27
PSA 36.612
NB_HD 0
NB_HA 4
fsp3 0.06
Lipinski(0=no;1=yes) 1
NB_atoms 21
XLogP 3.27
PSA 36.612
NB_HD 0
NB_HA 4
fsp3 0.06
Lipinski(0=no;1=yes) 1
FDA
NDA 019080 (pdf not found) INN (ESTAZOLAM) PROSOM (ABBOTT) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 074818 (pdf not found) INN (ESTAZOLAM) ESTAZOLAM (WATSON LABS) APPROVAL= AP YEAR= 1997
NDA 074826 (pdf not found) INN (ESTAZOLAM) ESTAZOLAM (NOVITIUM PHARMA) APPROVAL= AP YEAR= 1997
NDA 074921 (pdf not found) INN (ESTAZOLAM) ESTAZOLAM (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1997
NDA 019080 (pdf not found) INN (ESTAZOLAM) PROSOM (ABBOTT) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 074818 (pdf not found) INN (ESTAZOLAM) ESTAZOLAM (WATSON LABS) APPROVAL= AP YEAR= 1997
NDA 074826 (pdf not found) INN (ESTAZOLAM) ESTAZOLAM (NOVITIUM PHARMA) APPROVAL= AP YEAR= 1997
NDA 074921 (pdf not found) INN (ESTAZOLAM) ESTAZOLAM (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1997