e-Drug3D

57

cas 7683-59-2

CLASS

RESPIRATORY SYSTEM
BRONCHODILATOR
NON SELECTIVE BETA ADRENERGIC RECEPTOR AGONIST
SYMPATHOMIMETIC AMINE

ROUTE (list)

INHALATION RECTAL SUBLINGUAL INJECTION

PK parameters

VD 97.5 LITER (65 KILOGRAM)
Cl 218.4 LITER / HOUR (65 KILOGRAM)
PPB 29 PERCENT
t1/2 0.41 HOUR

TARGET BETA ADRENERGIC RECEPTOR

PDB
4A7T (STRUCTURE OF HUMAN I113T SOD1 MUTANT COMPLEXED WITH ISOPROTERANOL IN THE P21 SPACE GROUP)

Ligand code = 5FW (link to the list of PDB complexes)

Download experimental 3D coordinates of 5FW with added hydrogens

MW 211.26
NB_atoms 15
XLogP 1.13
PSA 75.45
NB_HD 4
NB_HA 4
fsp3 0.45
Lipinski(0=no;1=yes) 1

FDA
NDA 006327 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISUPREL (SANOFI AVENTIS US) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 007245 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) AEROLONE (LILLY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 011178 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISUPREL (SANOFI AVENTIS US) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 016813 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) VAPO-ISO (FISONS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 016814 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) NORISODRINE AEROTROL (ABBOTT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 017366 (pdf not found) INN (ACETYLCYSTEINE ; ISOPROTERENOL HYDROCHLORIDE) MUCOMYST W/ ISOPROTERENOL (MEAD JOHNSON) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083431 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (ABRAXIS PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085540 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (PARKE DAVIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085904 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (ALPHARMA US PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085994 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (PARKE DAVIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086764 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (DEY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 087935 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (ARMOUR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 006328 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISUPREL (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1948 DISCONTINUED
NDA 010375 (pdf not found) INN (ISOPROTERENOL SULFATE) MEDIHALER-ISO (3M) APPROVAL= AP YEAR= 1956 DISCONTINUED
NDA 010515 (label) INN (ISOPROTERENOL HYDROCHLORIDE) ISUPREL (BAUSCH) APPROVAL= AP YEAR= 1956 DISCONTINUED
NDA 013296 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE ; PHENYLEPHRINE BITARTRATE) DUO-MEDIHALER (3M) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 083283 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 083486 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (BAXTER HLTHCARE) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 006905 (pdf not found) INN (ISOPROTERENOL SULFATE) NORISODRINE (ABBVIE) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 083346 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 083724 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (INTL MEDICATION) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 087936 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (ARMOUR PHARM) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 206961 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (NEXUS) APPROVAL= AP YEAR= 2017
NDA 210106 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (AMPHASTAR PHARMS INC) APPROVAL= AP YEAR= 2018
NDA 210322 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (CIPLA) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 210576 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (AMNEAL) APPROVAL= AP YEAR= 2018
NDA 211738 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (CIPLA) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 210845 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (MICRO LABS) APPROVAL= AP YEAR= 2021
NDA 211237 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (AMRING PHARMS) APPROVAL= AP YEAR= 2021
NDA 211864 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 212189 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2021
NDA 212573 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 214775 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (AM REGENT) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 215542 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (PENN LIFE) APPROVAL= AP YEAR= 2022
NDA 211703 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2023
NDA 215557 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 211590 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2024
NDA 217648 (pdf not found) INN (ISOPROTERENOL HYDROCHLORIDE) ISOPROTERENOL HYDROCHLORIDE (GLAND) APPROVAL= AP YEAR= 2024