e-Drug3D

565

BEPRIDIL

DISCONTINUED

INN
BEPRIDIL

cas 64706-54-3

CLASS

CARDIOVASCULAR
ANTIARRHYTHMIC
VASODILATOR
ANTIANGINAL
CALCIUM CHANNEL BLOCKERS

ROUTE (list)

ORAL

ATC code

C08EA02

PK parameters

PPB 99 PERCENT
t1/2 42 HOUR

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

TARGET CALCIUM CHANNEL

PDB
1LXF (STRUCTURE OF THE REGULATORY N-DOMAIN OF HUMAN CARDIAC TROPONIN C IN COMPLEX WITH HUMAN CARDIAC TROPONIN-I(147-163) AND BEPRIDIL)

Ligand code = BEP (link to the list of PDB complexes)

Download experimental 3D coordinates of BEP with added hydrogens

DrugCentral

Voltage-dependent T-type calcium channel subunit alpha-1H UNIPROT O95180 CACNA1H

Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C

Download SDF file

N-[3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl]-N-(phenylmethyl)aniline

Formula:
C24H34N2O

Calculated chemical properties:

MW 366.53
NB_atoms 27
XLogP 4.83
PSA 14.901
NB_HD 0
NB_HA 3
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 019001 (pdf not found) INN (BEPRIDIL HYDROCHLORIDE) BEPADIN (MEDPOINTE PHARM HLC) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 019002 (pdf not found) INN (BEPRIDIL HYDROCHLORIDE) VASCOR (JOHNSON AND JOHNSON) APPROVAL= AP YEAR= 1990 DISCONTINUED