e-Drug3D

563

cas 1951-25-3

CLASS

CARDIOVASCULAR
ANTIARRHYTHMIC CLASS III

ROUTE (list)

ORAL INJECTION

PK parameters

F 50 PERCENT
Tmax 5 HOUR
VD 3900 LITER (65 KILOGRAM)
Cl 21.4 LITER / HOUR (65 KILOGRAM)
PPB 96 PERCENT
t1/2 1392 HOUR

TARGET SODIUM CHANNEL
POTASSIUM CHANNEL

PDB
4O8Z (CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH COMPOUND (2-BUTYLBENZOFURAN-3-YL)(4-(2-(DIETHYLAMINO)ETHOXY)-3,5-DIIODOPHENYL)METHANONE)

Ligand code = BBI (link to the list of PDB complexes)

Download experimental 3D coordinates of BBI with added hydrogens

MW 645.29
NB_atoms 31
XLogP 6.94
PSA 41.986
NB_HD 0
NB_HA 4
fsp3 0.40
Lipinski(0=no;1=yes) 0

FDA
NDA 018972 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) CORDARONE (WYETH PHARMS) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 020377 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) CORDARONE (WYETH PHARMS INC) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074739 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (TEVA PHARMS) APPROVAL= AP YEAR= 1998
NDA 075135 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) PACERONE (UPSHER SMITH LABS) APPROVAL= AP YEAR= 1998
NDA 075315 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (UPSHER SMITH LABS) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 074895 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (TEVA) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075188 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075389 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2001
NDA 075424 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (TARO) APPROVAL= AP YEAR= 2001
NDA 075761 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2002
NDA 075955 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076018 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (BEDFORD) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076088 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (BEN VENUE) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076108 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076217 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (MYLAN INSTITUTIONAL) APPROVAL= AP YEAR= 2002
NDA 076299 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (BEDFORD LABS) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076362 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (TARO) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076163 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076394 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (PAR STERILE PRODUCTS) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 021594 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (INTL MEDICATION SYS) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 077069 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2005
NDA 077161 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (GLAND PHARMA LTD) APPROVAL= AP YEAR= 2005
NDA 076232 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077234 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2008
NDA 079029 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2008
NDA 022325 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) NEXTERONE (BAXTER HLTHCARE) APPROVAL= AP YEAR= 2008
NDA 077610 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (ACELLA) APPROVAL= AP YEAR= 2008
NDA 077834 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (ACELLA) APPROVAL= AP YEAR= 2008
NDA 078578 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2008
NDA 203884 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 203885 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 204742 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2016
NDA 204550 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 213446 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (UNICHEM) APPROVAL= AP YEAR= 2020
NDA 218253 (pdf not found) INN (AMIODARONE HYDROCHLORIDE) AMIODARONE HYDROCHLORIDE (ZHEJIANG POLY PHARM) APPROVAL= AP YEAR= 2024