e-Drug3D

562

cas 541-15-1

CLASS

METABOLISM
CARNITINE REPLENISHER
FACILITATE LONG-CHAIN FATTY ACID ENTRY INTO CELLULAR MITOCHONDRIA
LEVOCARNITINE CLEARS ACYLCOA COMPOUND

ROUTE (list)

ORAL INJECTION

PK parameters

F 15 PERCENT
Tmax 3.3 HOUR
Cl 4 LITER / HOUR
PPB 0 PERCENT
t1/2 17.4 HOUR

TARGET MITOCHONDRIAL CARNITINE/ACYLCARNITINE CARRIER PROTEIN
ORGANIC CATION/CARNITINE TRANSPORTER

PDB
2H3U (CRYSTAL STRUCTURE OF MURINE CARNITINE ACETYLTRANSFERASE IN COMPLEX WITH CARNITINE AND COA)

Ligand code = 152 (link to the list of PDB complexes)

Download experimental 3D coordinates of 152 with added hydrogens

MW 161.20
NB_atoms 11
XLogP -1.81
PSA 52.761
NB_HD 1
NB_HA 3
fsp3 0.86
Lipinski(0=no;1=yes) 1

FDA
NDA 018948 (pdf not found) INN (LEVOCARNITINE) CARNITOR (LEADIANT BIOSCI INC) APPROVAL= AP YEAR= 1985
NDA 019257 (pdf not found) INN (LEVOCARNITINE) CARNITOR (LEADIANT BIOSCI INC) APPROVAL= AP YEAR= 1986
NDA 020182 (pdf not found) INN (LEVOCARNITINE) CARNITOR (LEADIANT BIOSCI INC) APPROVAL= AP YEAR= 1992
NDA 075567 (pdf not found) INN (LEVOCARNITINE) LEVOCARNITINE (HIKMA) APPROVAL= AP YEAR= 2001
NDA 075861 (pdf not found) INN (LEVOCARNITINE) LEVOCARNITINE (AM REGENT) APPROVAL= AP YEAR= 2001
NDA 075881 (pdf not found) INN (LEVOCARNITINE) LEVOCARNITINE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 076851 (pdf not found) INN (LEVOCARNITINE) LEVOCARNITINE (RISING) APPROVAL= AP YEAR= 2004
NDA 076858 (pdf not found) INN (LEVOCARNITINE) LEVOCARNITINE (RISING) APPROVAL= AP YEAR= 2004
NDA 077399 (pdf not found) INN (LEVOCARNITINE) LEVOCARNITINE (HIKMA) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 211676 (pdf not found) INN (LEVOCARNITINE) LEVOCARNITINE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2019
NDA 212533 (pdf not found) INN (LEVOCARNITINE) LEVOCARNITINE (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2021
NDA 216384 (pdf not found) INN (LEVOCARNITINE) LEVOCARNITINE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2022
NDA 217430 (pdf not found) INN (LEVOCARNITINE) LEVOCARNITINE (DEVA HOLDING AS) APPROVAL= AP YEAR= 2025