e-Drug3D

558

ACEBUTOLOL

INN
ACEBUTOLOL

(has an active metabolite)

cas 37517-30-9

CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE
ANTIANGINAL
ANTIARRHYTHMIC
ADRENERGIC (BETA) BLOCKER

ROUTE (list)

ORAL

ATC code

C07AB04
C07BB04

PK parameters

F 40 PERCENT
Tmax 2.5 HOUR
VD 102 LITER
Cl 36 LITER / HOUR
PPB 26 PERCENT
t1/2 3.5 HOUR

Solubility

FREELY SOLUBLE IN WATER

Target

TARGET BETA-1 ADRENERGIC RECEPTOR

DrugCentral

Beta-1 adrenergic receptor UNIPROT P08588 ADRB1

Download SDF file

N-[3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]butanamide

Formula:
C18H28N2O4

Calculated chemical properties:

MW 336.42
NB_atoms 24
XLogP 2.37
PSA 86.605
NB_HD 3
NB_HA 6
fsp3 0.56
Lipinski(0=no;1=yes) 1

FDA
NDA 018917 (pdf not found) INN (ACEBUTOLOL HYDROCHLORIDE) SECTRAL (PROMIUS PHARMA) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 074007 (pdf not found) INN (ACEBUTOLOL HYDROCHLORIDE) ACEBUTOLOL HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1995
NDA 074288 (pdf not found) INN (ACEBUTOLOL HYDROCHLORIDE) ACEBUTOLOL HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 075047 (pdf not found) INN (ACEBUTOLOL HYDROCHLORIDE) ACEBUTOLOL HYDROCHLORIDE (AMNEAL PHARM) APPROVAL= AP YEAR= 1999