e-Drug3D

555

cas 36791-04-5

CLASS

ANTIINFECTIVES
ANTIVIRAL
ANTIMETABOLITES
TREATMENT OF CHRONIC HEPATITIS C

ROUTE (list)

INHALATION ORAL

PK parameters

F 64 PERCENT
Tmax 1.7 HOUR
VD 2825 LITER
Cl 38.2 LITER / HOUR
PPB 0 PERCENT
t1/2 43.6 HOUR

TARGET ADENOSINE KINASE
CYTOSOLIC PURINE 5'-NUCLEOTIDASE
RNA-DIRECTED RNA POLYMERASE CATALYTIC SUBUNIT
ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 1
LARGE STRUCTURAL PROTEIN
INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1
DNA

PDB
3SFU (CRYSTAL STRUCTURE OF MURINE NOROVIRUS RNA DEPENDENT RNA POLYMERASE IN COMPLEX WITH RIBAVIRIN)

Ligand code = RBV (link to the list of PDB complexes)

Download experimental 3D coordinates of RBV with added hydrogens

MW 244.22
NB_atoms 17
XLogP -3.01
PSA 141.079
NB_HD 5
NB_HA 9
fsp3 0.62
Lipinski(0=no;1=yes) 0

FDA
NDA 018859 (pdf not found) INN (RIBAVIRIN) VIRAZOLE (BAUSCH) APPROVAL= AP YEAR= 1985
NDA 020903 (pdf not found) INN (RIBAVIRIN) REBETOL (MERCK SHARP DOHME) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 021511 (pdf not found) INN (RIBAVIRIN) COPEGUS (ROCHE) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021546 (pdf not found) INN (RIBAVIRIN) REBETOL (SCHERING) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076192 (pdf not found) INN (RIBAVIRIN) RIBAVIRIN (CHARTWELL RX) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076203 (pdf not found) INN (RIBAVIRIN) RIBASPHERE (CHARTWELL RX) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076277 (pdf not found) INN (RIBAVIRIN) RIBAVIRIN (TEVA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 125083 (pdf not found) INN (RIBAVIRIN) PEGINTERFERON (HOFFMAN-LA ROCHE) APPROVAL= AP YEAR= 2004 OBSOLETE
NDA 077053 (pdf not found) INN (RIBAVIRIN) RIBAVIRIN (HERITAGE PHARMA AVET) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077094 (pdf not found) INN (RIBAVIRIN) RIBAVIRIN (ZYDUS PHARMS USA) APPROVAL= AP YEAR= 2005
NDA 077224 (pdf not found) INN (RIBAVIRIN) RIBAVIRIN (ZYDUS PHARMS USA) APPROVAL= AP YEAR= 2005
NDA 077456 (pdf not found) INN (RIBAVIRIN) RIBAVIRIN (CHARTWELL RX) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077743 (pdf not found) INN (RIBAVIRIN) RIBAVIRIN (SANDOZ) APPROVAL= AP YEAR= 2006
NDA 125196 (pdf not found) INN (RIBAVIRIN) PEGINTRON/REBETOL COMBO PACK (SCHERING) APPROVAL= AP YEAR= 2008 OBSOLETE
NDA 079111 (pdf not found) INN (RIBAVIRIN) RIBAVIRIN (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2009
NDA 079117 (pdf not found) INN (RIBAVIRIN) RIBAVIRIN (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2009
NDA 077611 (pdf not found) INN (RIBAVIRIN) RIBAVIRIN (TEVA PHARMS) APPROVAL= TA YEAR= 2011
NDA 202546 (pdf not found) INN (RIBAVIRIN) RIBAVIRIN (BEXIMCO PHARMS USA) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 207366 (pdf not found) INN (RIBAVIRIN) RIBAVIRIN (NAVINTA LLC) APPROVAL= AP YEAR= 2016