e-Drug3D

551

cas 33419-42-0

CLASS

ANTINEOPLASTIC
NUCLEIC ACID SYNTHESIS INHIBITORS
INDUCTION OF DNA STRAND BREAKS BY AN INTERACTION WITH DNA-TOPOISOMERASE II OR THE FORMATION OF FREE RADICALS

ROUTE (list)

INJECTION ORAL

PK parameters

VD 23.5 LITER
Cl 2.4 LITER / HOUR
PPB 88 PERCENT
t1/2 7.5 HOUR

TARGET DNA TOPOISOMERASE 2

PDB
5CDN (2.8A STRUCTURE OF ETOPOSIDE WITH S.AUREUS DNA GYRASE AND DNA)

Ligand code = EVP (link to the list of PDB complexes)

Download experimental 3D coordinates of EVP with added hydrogens

MW 588.55
NB_atoms 42
XLogP 1.34
PSA 173.325
NB_HD 3
NB_HA 13
fsp3 0.55
Lipinski(0=no;1=yes) 0

FDA
NDA 074228 (pdf not found) INN (ETOPOSIDE) ETOPOSIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018768 (pdf not found) INN (ETOPOSIDE) VEPESID (CORDEN PHARMA) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 019557 (pdf not found) INN (ETOPOSIDE) VEPESID (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 074284 (pdf not found) INN (ETOPOSIDE) ETOPOSIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074166 (pdf not found) INN (ETOPOSIDE) TOPOSAR (TEVA PARENTERAL) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074290 (pdf not found) INN (ETOPOSIDE) ETOPOSIDE (HIKMA) APPROVAL= AP YEAR= 1995
NDA 074320 (pdf not found) INN (ETOPOSIDE) ETOPOSIDE (HOSPIRA) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074351 (pdf not found) INN (ETOPOSIDE) ETOPOSIDE (HOSPIRA) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074510 (pdf not found) INN (ETOPOSIDE) ETOPOSIDE (TEVA PARENTERAL) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074227 (pdf not found) INN (ETOPOSIDE) ETOPOSIDE (PHARMACHEMIE BV) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074513 (pdf not found) INN (ETOPOSIDE) ETOPOSIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 1996
NDA 074529 (pdf not found) INN (ETOPOSIDE) ETOPOSIDE (MEITHEAL) APPROVAL= AP YEAR= 1996
NDA 074813 (pdf not found) INN (ETOPOSIDE) ETOPOSIDE (PIERRE FABRE) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074968 (pdf not found) INN (ETOPOSIDE) ETOPOSIDE (WATSON LABS INC) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 074983 (pdf not found) INN (ETOPOSIDE) ETOPOSIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1998
NDA 075635 (pdf not found) INN (ETOPOSIDE) ETOPOSIDE (MYLAN) APPROVAL= AP YEAR= 2001
NDA 203507 (pdf not found) INN (ETOPOSIDE) ETOPOSIDE (DASH PHARMS NATCO) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 204927 (pdf not found) INN (ETOPOSIDE) ETOPOSIDE (DASH PHARMS) APPROVAL= AP YEAR= 2017 DISCONTINUED