e-Drug3D

549

cas 22071-15-4

CLASS

MUSCULO-SKELETEL SYSTEM
NSAID
ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL
CYCLOOXYGENASE INHIBITORS
ANTIRHEUMATIC
ANTIPYRETIC
ANALGESIC
INHIBITORY EFFECTS ON PROSTAGLANDIN AND LEUKOTRIENE SYNTHESIS AND ANTIBRADYKININ ACTIVITY

ROUTE (list)

ORAL

PK parameters

F 90 PERCENT
Tmax 1.25 HOUR
VD 6.5 LITER (65 KILOGRAM)
Cl 6.9 LITER / HOUR
PPB 99 PERCENT
t1/2 3.5 HOUR

TARGET PROSTAGLANDIN G/H SYNTHASE 1
PROSTAGLANDIN G/H SYNTHASE 2

PDB
5ZWR (STRUCTURAL BASIS FOR THE ENANTIOSELECTIVITY OF EST-Y29 TOWARD (S)-KETOPROFEN)

Ligand code = 9KL (link to the list of PDB complexes)

Download experimental 3D coordinates of 9KL with added hydrogens

MW 253.26
NB_atoms 19
XLogP 1.77
PSA 51.971
NB_HD 0
NB_HA 3
fsp3 0.12
Lipinski(0=no;1=yes) 1

FDA
NDA 018754 (pdf not found) INN (KETOPROFEN) ORUDIS (WYETH AYERST) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 073515 (pdf not found) INN (KETOPROFEN) KETOPROFEN (TEVA) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 073516 (pdf not found) INN (KETOPROFEN) KETOPROFEN (TEVA) APPROVAL= AP YEAR= 1992
NDA 073517 (pdf not found) INN (KETOPROFEN) KETOPROFEN (TEVA) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 019816 (pdf not found) INN (KETOPROFEN) ORUVAIL (WYETH PHARMS INC) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 074014 (pdf not found) INN (KETOPROFEN) KETOPROFEN (MISEMER) APPROVAL= AP YEAR= 1993
NDA 020429 (pdf not found) INN (KETOPROFEN) ORUDIS KT (WYETH CONS) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 020499 (pdf not found) INN (KETOPROFEN) ACTRON (BAYER) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074024 (pdf not found) INN (KETOPROFEN) KETOPROFEN (RISING) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074035 (pdf not found) INN (KETOPROFEN) KETOPROFEN (RISING) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074879 (pdf not found) INN (KETOPROFEN) KETOPROFEN (ALKERMES GAINESVILLE) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 075270 (pdf not found) INN (KETOPROFEN) KETOPROFEN (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075364 (pdf not found) INN (KETOPROFEN) KETOPROFEN (PERRIGO) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075679 (pdf not found) INN (KETOPROFEN) KETOPROFEN (MYLAN) APPROVAL= AP YEAR= 2002
NDA 022470 (pdf not found) INN (KETOPROFEN) NEXCEDE (NOVARTIS) APPROVAL= AP YEAR= 2009 DISCONTINUED