e-Drug3D

546

cas 29342-05-0

CLASS

DERMATOLOGICALS
ANTIFUNGAL
CHELATION OF POLYVALENT CATIONS RESULTING IN THE INHIBITION OF THE METAL-DEPENDENT ENZYMES THAT ARE RESPONSIBLE FOR THE DEGRADATION OF PEROXIDES WITHIN THE FUNGAL CELL

ROUTE (list)

TOPICAL

PK parameters

F 1.3 PERCENT
t1/2 1.7 HOUR

-

PDB
6J10 (CICLOPIROX INHIBITS HEPATITIS B VIRUS SECRETION BY BLOCKING CAPSID ASSEMBLY)

Ligand code = B4O (link to the list of PDB complexes)

Download experimental 3D coordinates of B4O with added hydrogens

MW 207.27
NB_atoms 15
XLogP 2.44
PSA 37.989
NB_HD 1
NB_HA 3
fsp3 0.58
Lipinski(0=no;1=yes) 1

FDA
NDA 018748 (label) INN (CICLOPIROX) LOPROX (MEDIMETRIKS PHARMS) APPROVAL= AP YEAR= 1982 NEWMOLECULARENTITY
NDA 019824 (label) INN (CICLOPIROX) LOPROX (MEDIMETRIKS PHARMS) APPROVAL= AP YEAR= 1988
NDA 020519 (label) INN (CICLOPIROX) CICLOPIROX (ALVOGEN) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 021022 (label) INN (CICLOPIROX) PENLAC (VALEANT BERMUDA) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 021159 (label) INN (CICLOPIROX) LOPROX (BAUSCH) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076422 (pdf not found) INN (CICLOPIROX) CICLOPIROX (FOUGERA PHARMS) APPROVAL= AP YEAR= 2004
NDA 076435 (pdf not found) INN (CICLOPIROX) CICLOPIROX (FOUGERA PHARMS) APPROVAL= AP YEAR= 2004
NDA 076790 (pdf not found) INN (CICLOPIROX) CICLOPIROX (TARO) APPROVAL= AP YEAR= 2005
NDA 077092 (pdf not found) INN (CICLOPIROX) CICLOPIROX (TARO) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077364 (pdf not found) INN (CICLOPIROX) CICLOPIROX (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2006
NDA 077676 (pdf not found) INN (CICLOPIROX) CICLOPIROX (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2006
NDA 077623 (pdf not found) INN (CICLOPIROX) CICLOPIROX (PADAGIS US) APPROVAL= AP YEAR= 2007
NDA 077687 (pdf not found) INN (CICLOPIROX) CICLOPIROX (ENCUBE) APPROVAL= AP YEAR= 2007
NDA 078046 (pdf not found) INN (CICLOPIROX) CICLOPIROX (CHARTWELL RX) APPROVAL= AP YEAR= 2007
NDA 078079 (pdf not found) INN (CICLOPIROX) CICLOPIROX (TEVA PHARMS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078124 (pdf not found) INN (CICLOPIROX) CICLOPIROX (RISING) APPROVAL= AP YEAR= 2007
NDA 078144 (pdf not found) INN (CICLOPIROX) CICLOPIROX (TARO PHARM INDS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078172 (pdf not found) INN (CICLOPIROX) CICLOPIROX (ACELLA) APPROVAL= AP YEAR= 2007
NDA 078233 (pdf not found) INN (CICLOPIROX) CICLOPIROX (COSETTE) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078270 (pdf not found) INN (CICLOPIROX) CICLOPIROX (HIKMA) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078567 (pdf not found) INN (CICLOPIROX) CICLOPIROX (MYLAN PHARMS INC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077896 (pdf not found) INN (CICLOPIROX) CICLOPIROX (FOUGERA PHARMS) APPROVAL= AP YEAR= 2008
NDA 078266 (pdf not found) INN (CICLOPIROX) CICLOPIROX (PADAGIS US) APPROVAL= AP YEAR= 2009
NDA 090273 (pdf not found) INN (CICLOPIROX) CICLOPIROX (GLENMARK PHARMS) APPROVAL= AP YEAR= 2009
NDA 090490 (pdf not found) INN (CICLOPIROX) CICLOPIROX (ACTAVIS MID ATLANTIC) APPROVAL= AP YEAR= 2009
NDA 078594 (pdf not found) INN (CICLOPIROX) CICLOPIROX (PADAGIS US) APPROVAL= AP YEAR= 2010
NDA 078975 (pdf not found) INN (CICLOPIROX) CICLOPIROX (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090146 (pdf not found) INN (CICLOPIROX) CICLOPIROX (FOUGERA PHARMS) APPROVAL= AP YEAR= 2010
NDA 078463 (pdf not found) INN (CICLOPIROX) CICLOPIROX (COSETTE) APPROVAL= AP YEAR= 2010
NDA 090269 (pdf not found) INN (CICLOPIROX) CICLOPIROX (TARO) APPROVAL= AP YEAR= 2011
NDA 091595 (pdf not found) INN (CICLOPIROX) CICLOPIROX (GLENMARK PHARMS INC) APPROVAL= AP YEAR= 2012
NDA 209975 (pdf not found) INN (CICLOPIROX) CICLOPIROX (ENCUBE) APPROVAL= AP YEAR= 2018 DISCONTINUED