e-Drug3D

545

NAPHAZOLINE


INN
NAPHAZOLINE

cas 835-31-4
CLASS

RESPIRATORY SYSTEM
ALPHA ADRENERGIC RECEPTOR AGONIST
ANTIALLERGIC

ROUTE (list)

OPHTHALMIC

ATC code

R01AA08
R01AB02
S01GA01
S01GA51

PK parameters

Solubility

FREELY SOLUBLE IN WATER


Target

TARGET ALPHA 2 ADRENERGIC RECEPTOR (PMID241844
PMID17852165)

DrugCentral

Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A

Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B

Download SDF file 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-

Formula:
C14H14N2

Calculated chemical properties:

MW 210.27
NB_atoms 16
XLogP 2.38
PSA 24.694
NB_HD 1
NB_HA 2
fsp3 0.21
Lipinski(0=no;1=yes) 1

FDA
NDA 088101 (pdf not found) INN (NAPHAZOLINE HYDROCHLORIDE) NAFAZAIR (PHARMAFAIR) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 080235 (pdf not found) INN (NAPHAZOLINE HYDROCHLORIDE) VASOCON (NOVARTIS) APPROVAL= AP YEAR= 1971 DISCONTINUED
NDA 080248 (pdf not found) INN (NAPHAZOLINE HYDROCHLORIDE) ALBALON (ALLERGAN) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080229 (pdf not found) INN (NAPHAZOLINE HYDROCHLORIDE) NAPHCON FORTE (ALCON) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 083590 (pdf not found) INN (NAPHAZOLINE HYDROCHLORIDE) NAPHAZOLINE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 087506 (pdf not found) INN (NAPHAZOLINE HYDROCHLORIDE) OPCON (BAUSCH AND LOMB) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 018746 (pdf not found) INN (ANTAZOLINE PHOSPHATE ; NAPHAZOLINE HYDROCHLORIDE) VASOCON-A (NOVARTIS) APPROVAL= AP YEAR= 1990 NEWAPPLICATION DISCONTINUED
NDA 020065 (pdf not found) INN (NAPHAZOLINE HYDROCHLORIDE ; PHENIRAMINE MALEATE) OPCON-A (BAUSCH AND LOMB) APPROVAL= AP YEAR= 1994
NDA 020226 (pdf not found) INN (NAPHAZOLINE HYDROCHLORIDE ; PHENIRAMINE MALEATE) NAPHCON-A (ALCON) APPROVAL= AP YEAR= 1994
NDA 040073 (pdf not found) INN (NAPHAZOLINE HYDROCHLORIDE) NAFAZAIR (BAUSCH AND LOMB) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 020485 (pdf not found) INN (NAPHAZOLINE HYDROCHLORIDE ; PHENIRAMINE MALEATE) VISINE (KENVUE BRANDS) APPROVAL= AP YEAR= 1996
NDA 078208 (pdf not found) INN (NAPHAZOLINE HYDROCHLORIDE ; PHENIRAMINE MALEATE) NAPHAZOLINE HYDROCHLORIDE AND PHENIRAMINE MALEATE (ALTAIRE PHARMS INC) APPROVAL= AP YEAR= 2010
NDA 202795 (pdf not found) INN (NAPHAZOLINE HYDROCHLORIDE ; PHENIRAMINE MALEATE) NAPHAZOLINE HYDROCHLORIDE AND PHENIRAMINE MALEATE (RISING) APPROVAL= AP YEAR= 2013

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL