e-Drug3D

542

cas 36505-84-7

CLASS

NERVOUS SYSTEM
5HT1A RECEPTOR AGONIST
ANXIOLYTIC
SEROTONIN AGONISTS

ROUTE (list)

ORAL

PK parameters

F 90 PERCENT
Tmax 1 HOUR
PPB 86 PERCENT
t1/2 2.5 HOUR

TARGET 5-HYDROXYTRYPTAMINE 1A RECEPTOR

PDB
8FYX (BUSPIRONE-BOUND SEROTONIN 1A (5-HT1A) RECEPTOR-GI1 PROTEIN COMPLEX)

Ligand code = YLX (link to the list of PDB complexes)

Download experimental 3D coordinates of YLX with added hydrogens

MW 385.51
NB_atoms 28
XLogP 2.09
PSA 64.412
NB_HD 0
NB_HA 7
fsp3 0.71
Lipinski(0=no;1=yes) 1

FDA
NDA 018731 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPAR (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 074684 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HCL (NOVOPHARM LIMITED) APPROVAL= TA YEAR= 1998 OBSOLETE
NDA 075272 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 1998 OBSOLETE
NDA 021190 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPAR (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 074253 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (IMPAX LABS INC) APPROVAL= AP YEAR= 2001
NDA 075467 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 076008 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 2001
NDA 075022 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (TEVA) APPROVAL= AP YEAR= 2002
NDA 075119 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (EGIS) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075385 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075388 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (OXFORD PHARMS) APPROVAL= AP YEAR= 2002
NDA 075413 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075521 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2002
NDA 075572 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (NESHER PHARMS) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 078302 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (OXFORD PHARMS) APPROVAL= AP YEAR= 2007
NDA 078246 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2009
NDA 078888 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2014
NDA 202330 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 2014
NDA 202557 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2014
NDA 202087 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (AIPING PHARM INC) APPROVAL= AP YEAR= 2015
NDA 204582 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (HERITAGE PHARMA) APPROVAL= AP YEAR= 2015
NDA 208829 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (AMNEAL PHARMS CO) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 209696 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (INVENTIA HLTHCARE) APPROVAL= AP YEAR= 2018
NDA 208972 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2019
NDA 210907 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (UNICHEM) APPROVAL= AP YEAR= 2019
NDA 218628 (pdf not found) INN (BUSPIRONE HYDROCHLORIDE) BUSPIRONE HYDROCHLORIDE (PANGEA) APPROVAL= AP YEAR= 2025