e-Drug3D

539

PRAZIQUANTEL

INN
PRAZIQUANTEL

cas 55268-74-1

CLASS

ANTIPARASITIC
ANTHELMINTIC
TREATMENT OF OF SCHISTOSOME INFECTIONS AND INFECTIONS DUE TO LIVER FLUKE

ROUTE (list)

ORAL

ATC code

P02BA01

PK parameters

F 80 PERCENT
Tmax 2 HOUR
PPB 80 PERCENT
t1/2 1.1 HOUR

Solubility

VERY SLIGHTLY SOLUBLE IN WATER

Target

TARGET GLUTATHIONE S-TRANSFERASE

PDB
1GTB (GLUTATHIONE S-TRANSFERASE FROM SCHISTOSOMA JAPONICA)

Ligand code = - (link to the list of PDB complexes)

Download experimental 3D coordinates of - with added hydrogens

DrugCentral

High voltage-activated calcium channel beta subunit CavB1 UNIPROT Q95US7

High voltage-activated calcium channel beta subunit CavB2 UNIPROT Q962H3

Download SDF file

2-(cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[6,1-a]isoquinolin-4-one

Formula:
C19H24N2O2

Calculated chemical properties:

MW 312.40
NB_atoms 23
XLogP 2.53
PSA 38.009
NB_HD 0
NB_HA 4
fsp3 0.58
Lipinski(0=no;1=yes) 1

FDA
NDA 018714 (pdf not found) INN (PRAZIQUANTEL) BILTRICIDE (BAYER HLTHCARE) APPROVAL= AP YEAR= 1982 NEWMOLECULARENTITY DISCONTINUED
NDA 208820 (pdf not found) INN (PRAZIQUANTEL) PRAZIQUANTEL (PH HEALTH) APPROVAL= AP YEAR= 2017