e-Drug3D

533

NABILONE

DISCONTINUED

INN
NABILONE

cas 51022-71-0

CLASS

METABOLISM
ANXIOLYTIC
ANTIEMETIC
CANNABINOID RECEPTOR 1 AGONIST
TREATMENT OF NAUSEA AND VOMITING INDUCED BY CANCER CHEMOTHERAPY
SIMILAR TO THE ACTIVE INGREDIENT FOUND IN NATURALLY OCCURRING CANNABIS SATIVA L.

ROUTE (list)

ORAL

ATC code

A04AD11

PK parameters

Tmax 2 HOUR
VD 812 LITER (65 KILOGRAM)
Cl 281.3 LITER / HOUR (EQN)
t1/2 2 HOUR

Solubility

LESS THAN 0.5 MILLIGRAM / LITER

Target

TARGET CANNABINOID RECEPTOR 1

DrugCentral

Cannabinoid receptor 1 UNIPROT P21554 CNR1

Download SDF file

(6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-7,8,10,10a-tetrahydro-6aH-benzo[c]chromen-9-one

Formula:
C24H36O3

Calculated chemical properties:

MW 372.53
NB_atoms 27
XLogP 6.26
PSA 44.902
NB_HD 1
NB_HA 3
fsp3 0.71
Lipinski(0=no;1=yes) 0

FDA
NDA 018677 (label) INN (NABILONE) CESAMET (BAUSCH) APPROVAL= AP YEAR= 1985 NEWMOLECULARENTITY DISCONTINUED