e-Drug3D

529

cas 59467-70-8

CLASS

NERVOUS SYSTEM
ANESTHETIC
ANTI-ANXIETY AGENTS
GABA MODULATORS
HYPNOTICS AND SEDATIVES
BENZODIAZEPINE
TREATMENT OF CONVULSIVE SEIZURES (EPILEPSY)

ROUTE (list)

INJECTION ORAL INTRAMUSCULAR NASAL INTRAVENOUS

PK parameters

F 90 PERCENT
Tmax 0.5 HOUR
VD 133.2 LITER (65 KILOGRAM)
Cl 25.6 LITER / HOUR (65 KILOGRAM)
PPB 97 PERCENT
t1/2 4.1 HOUR

TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR

PDB
5TE8 (CRYSTAL STRUCTURE OF THE MIDAZOLAM-BOUND HUMAN CYP3A4)

Ligand code = 08J (link to the list of PDB complexes)

Download experimental 3D coordinates of 08J with added hydrogens

MW 325.76
NB_atoms 23
XLogP 4.32
PSA 24.852
NB_HD 0
NB_HA 3
fsp3 0.11
Lipinski(0=no;1=yes) 1

FDA
NDA 018654 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) VERSED (HLR) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 020942 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) VERSED (ROCHE) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 075263 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (IGI LABS INC) APPROVAL= TA YEAR= 1999
NDA 075154 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2000
NDA 075243 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2000
NDA 075247 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2000
NDA 075249 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (BEDFORD) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075293 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 2000
NDA 075324 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2000
NDA 075396 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075409 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (HOSPIRA INC) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075421 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2000
NDA 075455 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (BEN VENUE) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075481 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075484 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075494 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2000
NDA 075620 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (APOTHECON) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075637 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075641 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (APOTHECON) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075856 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075857 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE PRESERVATIVE FREE (HOSPIRA) APPROVAL= AP YEAR= 2002
NDA 075873 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2002
NDA 076058 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075958 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (PAI HOLDINGS) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076020 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (INTL MEDICATION) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076144 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (INTL MEDICATED) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 076379 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (PADAGIS US) APPROVAL= AP YEAR= 2005
NDA 077115 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (PHARM ASSOC) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 078141 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (PH HEALTH) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078511 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (PH HEALTH) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 090315 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE PRESERVATIVE FREE (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2010
NDA 090316 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDOZALAM HYDROCHLORIDE (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2011
NDA 090850 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (GLAND PHARMA LTD) APPROVAL= AP YEAR= 2012
NDA 090696 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (GLAND PHARMA LTD) APPROVAL= AP YEAR= 2012
NDA 203460 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE PRESERVATIVE FREE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2014
NDA 208878 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 209566 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) SEIZALAM (MMT) APPROVAL= AP YEAR= 2018 NEWAPPLICATION DISCONTINUED
NDA 211321 (pdf not found) INN (MIDAZOLAM) NAYZILAM (UCB INC) APPROVAL= AP YEAR= 2019
NDA 212847 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2020
NDA 211844 (pdf not found) INN (MIDAZOLAM) MIDAZOLAM IN 0.9% SODIUM CHLORIDE (INFORLIFE) APPROVAL= AP YEAR= 2021
NDA 215868 (pdf not found) INN (MIDAZOLAM) MIDAZOLAM IN 0.8% SODIUM CHLORIDE (EXELA PHARMA) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 216048 (pdf not found) INN (MIDAZOLAM) MIDAZOLAM (CIPLA LTD) APPROVAL= TA YEAR= 2022
NDA 216359 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE AUTOINJECTOR (RAFA LABS LTD) APPROVAL= AP YEAR= 2022
NDA 216159 (pdf not found) INN (MIDAZOLAM) MIDAZOLAM IN 0.9% SODIUM CHLORIDE (HIKMA) APPROVAL= AP YEAR= 2023
NDA 217504 (pdf not found) INN (MIDAZOLAM HYDROCHLORIDE) MIDAZOLAM HYDROCHLORIDE (MICRO LABS) APPROVAL= AP YEAR= 2023
NDA 218993 (pdf not found) INN (MIDAZOLAM) MIDAZOLAM IN 0.9% SODIUM CHLORIDE (GLAND) APPROVAL= AP YEAR= 2024
NDA 218454 (pdf not found) INN (MIDAZOLAM) MIDAZOLAM IN 0.8% SODIUM CHLORIDE (B BRAUN MEDICAL) APPROVAL= AP YEAR= 2025