e-Drug3D

527

cas 6493-05-6

CLASS

CARDIOVASCULAR
VASODILATOR
HEMORRHEOLOGIC AGENTS AFFECT BLOOD VISCOSITY
TREATMENT OF PATIENTS WITH INTERMITTENT CLAUDICATION ON THE BASIS OF CHRONIC OCCLUSIVE ARTERIAL DISEASE OF THE LIMBS
PHOSPHODIESTERASE INHIBITORS
ANTIMALARIALS

ROUTE (list)

ORAL

PK parameters

Tmax 1 HOUR
VD 117 LITER (65 KILOGRAM)
Cl 152 LITER / HOUR (65 KILOGRAM)
t1/2 0.6 HOUR

TARGET PHOSPHODIESTERASE

PDB
3ARR (CRYSTAL STRUCTURE ANALYSIS OF CHITINASE A FROM VIBRIO HARVEYI WITH NOVEL INHIBITORS - COMPLEX STRUCTURE WITH PENTOXIFYLLINE)

Ligand code = PNX (link to the list of PDB complexes)

Download experimental 3D coordinates of PNX with added hydrogens

MW 278.31
NB_atoms 20
XLogP 0.19
PSA 67.917
NB_HD 0
NB_HA 7
fsp3 0.54
Lipinski(0=no;1=yes) 1

FDA
NDA 018631 (label) INN (PENTOXIFYLLINE) TRENTAL (VALIDUS PHARMS) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 074425 (pdf not found) INN (PENTOXIFYLLINE) PENTOXIFYLLINE (RISING) APPROVAL= AP YEAR= 1997
NDA 074877 (pdf not found) INN (PENTOXIFYLLINE) PENTOXIFYLLINE (HERITAGE) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074878 (pdf not found) INN (PENTOXIFYLLINE) PENTOXIFYLLINE (ANI PHARMS) APPROVAL= AP YEAR= 1997
NDA 075028 (pdf not found) INN (PENTOXIFYLLINE) PENTOXIFYLLINE (VALEANT PHARMS) APPROVAL= AP YEAR= 1998
NDA 075107 (pdf not found) INN (PENTOXIFYLLINE) PENTOXIFYLLINE (ANI PHARMS) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 074874 (pdf not found) INN (PENTOXIFYLLINE) PENTOXIFYLLINE (PLIVA) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 074962 (label) INN (PENTOXIFYLLINE) PENTOXIL (UPSHER SMITH LABS) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075093 (pdf not found) INN (PENTOXIFYLLINE) PENTOXIFYLLINE (IMPAX LABS) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075191 (pdf not found) INN (PENTOXIFYLLINE) PENTOXIFYLLINE (APOTEX) APPROVAL= AP YEAR= 1999
NDA 075199 (pdf not found) INN (PENTOXIFYLLINE) PENTOXIFYLLINE (ANI PHARMS) APPROVAL= AP YEAR= 1999 DISCONTINUED