e-Drug3D

521

SULFADOXINE

DISCONTINUED

INN
SULFADOXINE

cas 2447-57-6

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
ANTIMALARIALS
DIHYDROPTEROATE SYNTHASE INHIBITOR

ROUTE (list)

ORAL

ATC code

P01BF09

PK parameters

Tmax 4 HOUR
VD 9.1 LITER (65 KILOGRAM)
Cl 0.03 LITER / HOUR (EQN)
PPB 90 PERCENT
t1/2 200 HOUR

Target

TARGET DIHYDROPTEROATE SYNTHASE

7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase

Download SDF file

4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide

Formula:
C12H14N4O4S

Calculated chemical properties:

MW 310.34
NB_atoms 21
XLogP 0.88
PSA 106.534
NB_HD 3
NB_HA 8
fsp3 0.17
Lipinski(0=no;1=yes) 1

FDA
NDA 018557 (label) INN (PYRIMETHAMINE ; SULFADOXINE) FANSIDAR (ROCHE) APPROVAL= AP YEAR= 1981 DISCONTINUED