e-Drug3D

516

cas 65277-42-1

CLASS

ANTIINFECTIVES
ANTIFUNGAL
OPICAL TREATMENT OF SEBORRHEIC DERMATITIS
IMPAIRS BIOSYNTHESIS OF ERGOSTEROL

ROUTE (list)

ORAL TOPICAL

PK parameters

Tmax 1.5 HOUR
PPB 99 PERCENT
t1/2 6.5 HOUR

TARGET CYTOCHROME P450 51

PDB
6AYB (NAEGLERIA FOWLERI CYP51-KETOCONAZOLE COMPLEX)

Ligand code = KKK (link to the list of PDB complexes)

Download experimental 3D coordinates of KKK with added hydrogens

MW 531.42
NB_atoms 36
XLogP 4.21
PSA 67.945
NB_HD 0
NB_HA 8
fsp3 0.38
Lipinski(0=no;1=yes) 0

FDA
NDA 070767 (pdf not found) INN (KETOCONAZOLE) NIZORAL (JANSSEN PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018533 (label) INN (KETOCONAZOLE) NIZORAL (JANSSEN PHARMS) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 019084 (pdf not found) INN (KETOCONAZOLE) NIZORAL (JANSSEN PHARMA) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 019927 (label) INN (KETOCONAZOLE) NIZORAL (JANSSEN PHARMS) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 020310 (label) INN (KETOCONAZOLE) NIZORAL ANTI-DANDRUFF (KRAMER) APPROVAL= AP YEAR= 1997
NDA 074971 (label) INN (KETOCONAZOLE) KETOCONAZOLE (CHARTWELL RX) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075273 (label) INN (KETOCONAZOLE) KETOCONAZOLE (TEVA) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075314 (pdf not found) INN (KETOCONAZOLE) KETOCONAZOLE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075319 (pdf not found) INN (KETOCONAZOLE) KETOCONAZOLE (TARO) APPROVAL= AP YEAR= 1999
NDA 075341 (pdf not found) INN (KETOCONAZOLE) KETOCONAZOLE (AAIPHARMA LLC) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075362 (pdf not found) INN (KETOCONAZOLE) KETOCONAZOLE (HERITAGE PHARMA) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075597 (pdf not found) INN (KETOCONAZOLE) KETOCONAZOLE (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075581 (label) INN (KETOCONAZOLE) KETOCONAZOLE (TEVA) APPROVAL= AP YEAR= 2000
NDA 075638 (pdf not found) INN (KETOCONAZOLE) KETOZOLE (TARO) APPROVAL= AP YEAR= 2002
NDA 075912 (pdf not found) INN (KETOCONAZOLE) KETOCONAZOLE (SENORES PHARMS) APPROVAL= AP YEAR= 2002
NDA 076294 (pdf not found) INN (KETOCONAZOLE) KETOCONAZOLE (FOUGERA PHARMS) APPROVAL= AP YEAR= 2004
NDA 076419 (pdf not found) INN (KETOCONAZOLE) KETOCONAZOLE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2004
NDA 076942 (pdf not found) INN (KETOCONAZOLE) KETOCONAZOLE (COSETTE) APPROVAL= AP YEAR= 2005
NDA 021946 (label) INN (KETOCONAZOLE) XOLEGEL (INA PHARMS) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 021738 (label) INN (KETOCONAZOLE) EXTINA (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 091550 (pdf not found) INN (KETOCONAZOLE) KETOCONAZOLE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2011
NDA 210457 (pdf not found) INN (KETOCONAZOLE) KETOCONAZOLE (STRIDES PHARMA) APPROVAL= AP YEAR= 2018
NDA 212443 (pdf not found) INN (KETOCONAZOLE) KETOCONAZOLE (ENCUBE) APPROVAL= AP YEAR= 2021
NDA 213601 (pdf not found) INN (KETOCONAZOLE) KETOCONAZOLE (XIROMED) APPROVAL= AP YEAR= 2021
NDA 215185 (pdf not found) INN (KETOCONAZOLE) KETOCONAZOLE (TRUPHARMA) APPROVAL= AP YEAR= 2021
NDA 218498 (pdf not found) INN (KETOCONAZOLE) KETOCONAZOLE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2024
NDA 218559 (pdf not found) INN (KETOCONAZOLE) KETOCONAZOLE (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2025
NDA 219129 (pdf not found) INN (KETOCONAZOLE) KETOCONAZOLE (ESJAY PHARMA) APPROVAL= AP YEAR= 2025