e-Drug3D

510

cas 21829-25-4

CLASS

CARDIOVASCULAR
CORONARY VASODILATOR
CALCIUM CHANNEL BLOCKERS
DIHYDROPYRIDINES

ROUTE (list)

ORAL

PK parameters

F 86 PERCENT
Tmax 0.5 HOUR
VD 51.3 LITER (65 KILOGRAM)
Cl 31.1 LITER / HOUR
PPB 95 PERCENT
t1/2 2 HOUR

TARGET VOLTAGE-DEPENDENT CALCIUM CHANNEL

PDB
6JP5 (RABBIT CAV1.1-NIFEDIPINE COMPLEX)

Ligand code = C5U (link to the list of PDB complexes)

Download experimental 3D coordinates of C5U with added hydrogens

MW 346.33
NB_atoms 25
XLogP 0
PSA 91.292
NB_HD 1
NB_HA 7
fsp3 0.29
Lipinski(0=no;1=yes) 1

FDA
NDA 018482 (label) INN (NIFEDIPINE) PROCARDIA (PFIZER) APPROVAL= AP YEAR= 1981
NDA 019478 (pdf not found) INN (NIFEDIPINE) ADALAT (BAYER PHARMS) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 019684 (label) INN (NIFEDIPINE) PROCARDIA XL (PFIZER) APPROVAL= AP YEAR= 1989
NDA 072409 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (CHASE LABS NJ) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072556 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072579 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1989
NDA 073250 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (VELZEN PHARMA PVT) APPROVAL= AP YEAR= 1991
NDA 073421 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (CHASE LABS NJ) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 072651 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (TEVA) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 074045 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (VELZEN PHARMA PVT) APPROVAL= AP YEAR= 1992
NDA 020198 (label) INN (NIFEDIPINE) ADALAT CC (NORWICH) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 072781 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (ACELLA) APPROVAL= AP YEAR= 1993
NDA 075108 (label) INN (NIFEDIPINE) NIFEDIPINE (PHARMOBEDIENT) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075128 (pdf not found) INN (NIFEDIPINE) AFEDITAB CR (WATSON LABS TEVA) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075269 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (VALEANT PHARMS NORTH) APPROVAL= AP YEAR= 2000
NDA 075289 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (VALEANT PHARMS NORTH) APPROVAL= AP YEAR= 2000
NDA 075659 (pdf not found) INN (NIFEDIPINE) AFEDITAB CR (WATSON LABS) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 076070 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (VALEANT PHARMS NORTH) APPROVAL= AP YEAR= 2002
NDA 075414 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (MARTEC USA LLC) APPROVAL= AP YEAR= 2004
NDA 077127 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (OSMOTICA PHARM US) APPROVAL= AP YEAR= 2005
NDA 077899 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (PH HEALTH) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077410 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (OSMOTICA PHARM US) APPROVAL= AP YEAR= 2007 OBSOLETE
NDA 090602 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (RISING) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090649 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 201071 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (RISING) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 202644 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (HERITAGE PHARMA) APPROVAL= AP YEAR= 2013
NDA 203126 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (TWI PHARMS) APPROVAL= AP YEAR= 2014
NDA 202987 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (NOVAST LABS) APPROVAL= AP YEAR= 2016
NDA 210012 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 210184 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2018
NDA 210614 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (NOVAST LABS) APPROVAL= AP YEAR= 2019
NDA 210838 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (SPIL) APPROVAL= AP YEAR= 2019
NDA 212016 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (ELITE PHARM SOLUTION) APPROVAL= AP YEAR= 2020
NDA 213361 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2021
NDA 216067 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2022
NDA 216019 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (SWISS PHARM) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 216896 (pdf not found) INN (NIFEDIPINE) NIFEDIPINE (ALEMBIC) APPROVAL= AP YEAR= 2022