e-Drug3D

509

OXYMETAZOLINE

INN
OXYMETAZOLINE

cas 1491-59-4

CLASS

RESPIRATORY SYSTEM
ADRENERGIC ALPHA 1 AND ALPHA 2 AGONIST
NASAL DECONGESTANT

ROUTE (list)

OPHTHALMIC NASAL TOPICAL

ATC code

D11AX27
R01AA05
R01AB07
S01GA04

PK parameters

Target

TARGET ALPHA-2A ADRENERGIC RECEPTOR
ALPHA-1A ADRENERGIC RECEPTOR

PDB
7EJK (STRUCTURE OF THE ALPHA2A-ADRENERGIC RECEPTOR GOA SIGNALING COMPLEX BOUND TO OXYMETAZOLINE)

Ligand code = J5C (link to the list of PDB complexes)

Download experimental 3D coordinates of J5C with added hydrogens

DrugCentral

Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A

Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B

Download SDF file

6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol

Formula:
C16H24N2O

Calculated chemical properties:

MW 260.37
NB_atoms 19
XLogP 2.85
PSA 40.388
NB_HD 2
NB_HA 3
fsp3 0.56
Lipinski(0=no;1=yes) 1

FDA
NDA 018471 (pdf not found) INN (OXYMETAZOLINE HYDROCHLORIDE) OCUCLEAR (BAYER HEALTHCARE LLC) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 019407 (pdf not found) INN (OXYMETAZOLINE HYDROCHLORIDE) VISINE L.R. (KENVUE BRANDS) APPROVAL= AP YEAR= 1989
NDA 208032 (pdf not found) INN (OXYMETAZOLINE HYDROCHLORIDE ; TETRACAINE HYDROCHLORIDE) KOVANAZE (ST RENATUS) APPROVAL= AP YEAR= 2016
NDA 208552 (pdf not found) INN (OXYMETAZOLINE HYDROCHLORIDE) RHOFADE (MAYNE PHARMA) APPROVAL= AP YEAR= 2017 NEWAPPLICATION
NDA 212520 (pdf not found) INN (OXYMETAZOLINE HYDROCHLORIDE) UPNEEQ (RVL PHARMS) APPROVAL= AP YEAR= 2020
NDA 213584 (pdf not found) INN (OXYMETAZOLINE HYDROCHLORIDE) OXYMETAZOLINE HYDROCHLORIDE (TARO) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 211812 (pdf not found) INN (OXYMETAZOLINE) OXYMETAZOLINE (TEVA PHARMS USA INC) APPROVAL= TA YEAR= 2022