e-Drug3D

507

cas 25812-30-0

CLASS

CARDIOVASCULAR
HYPOLIPIDEMIC
FRIBIC ACID DERIVATIVES
STIMULATING THE EXPRESSION OF MYELIN-SPECIFIC GENES

ROUTE (list)

ORAL

PK parameters

F 100 PERCENT
Tmax 1.5 HOUR
VD 11 LITER
Cl 7.8 LITER / HOUR
PPB 98 PERCENT
t1/2 1.5 HOUR

TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA

PDB
5BOJ (CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH GEMFIBROZIL)

Ligand code = 4TX (link to the list of PDB complexes)

Download experimental 3D coordinates of 4TX with added hydrogens

MW 249.32
NB_atoms 18
XLogP 2.24
PSA 44.833
NB_HD 0
NB_HA 3
fsp3 0.53
Lipinski(0=no;1=yes) 1

FDA
NDA 074156 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 074360 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018422 (label) INN (GEMFIBROZIL) LOPID (PFIZER PHARMS) APPROVAL= AP YEAR= 1981
NDA 072929 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (PUREPAC PHARM) APPROVAL= TA YEAR= 1991
NDA 073466 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (NATCO) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 074256 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (TEVA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 074270 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (CHARTWELL MOLECULES) APPROVAL= AP YEAR= 1993
NDA 074442 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (WATSON LABS) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074452 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (PHARMOBEDIENT) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074615 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (CHARTWELL RX) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 075034 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (APOTEX) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 077836 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (INVAGEN PHARMS) APPROVAL= AP YEAR= 2006
NDA 078012 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2007
NDA 078207 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (IMPAX PHARMS) APPROVAL= AP YEAR= 2007
NDA 079239 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078599 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (HIKMA PHARMS) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 079072 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (NORTHSTAR HLTHCARE) APPROVAL= AP YEAR= 2010
NDA 202726 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2015
NDA 203266 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (CADILA PHARMS LTD) APPROVAL= AP YEAR= 2016
NDA 204189 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (CADILA) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 214603 (pdf not found) INN (GEMFIBROZIL) GEMFIBROZIL (ASCENT PHARMS INC) APPROVAL= AP YEAR= 2021