e-Drug3D

505

VERAPAMIL


INN
VERAPAMIL

cas 52-53-9
CLASS

CARDIOVASCULAR
CALCIUM ION INFLUX INHIBITOR
L-TYPE CALCIUM CHANNEL BLOCKER
CORONARY VASODILATOR
ANTIARRHYTHMIC

ROUTE (list)

INJECTION ORAL INTRAVENOUS

ATC code

C09BB10
C08DA01
C08DA51

PK parameters

F 13 PERCENT
Tmax 1.5 HOUR
VD 240.5 LITER (65 KILOGRAM)
Cl 70.2 LITER / HOUR (65 KILOGRAM)
PPB 90 PERCENT
t1/2 5.1 HOUR

Solubility

SOLUBLE IN WATER


Target

TARGET VOLTAGE-DEPENDENT CALCIUM CHANNEL

PDB
5C6O (PROTEIN B)

Ligand code = 4YH (link to the list of PDB complexes)

Download experimental 3D coordinates of 4YH with added hydrogens

DrugCentral

Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C

Voltage-dependent L-type calcium channel subunit alpha-1S UNIPROT Q13698 CACNA1S

Download SDF file 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile

Formula:
C27H38N2O4

Calculated chemical properties:

MW 454.59
NB_atoms 33
XLogP 5.09
PSA 67.487
NB_HD 0
NB_HA 6
fsp3 0.52
Lipinski(0=no;1=yes) 0

FDA
NDA 070348 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (ABRAXIS PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070672 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HCL (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070695 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (SOLOPAK) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070696 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (SMITH AND NEPHEW) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070697 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (SMITH AND NEPHEW) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072799 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018485 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) ISOPTIN (MT ADAMS) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 018593 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) ISOPTIN (MT ADAMS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 018817 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) CALAN (PFIZER) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 018925 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (EXELA PHARMA) APPROVAL= AP YEAR= 1984
NDA 019038 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) CALAN (GD SEARLE LLC) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 070225 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (LUITPOLD) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070451 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (INTL MEDICATION) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 070617 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (LUITPOLD) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 019152 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) CALAN SR (PFIZER) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070340 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (WARNER CHILCOTT) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070341 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (WARNER CHILCOTT) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070468 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070482 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (MUTUAL PHARM) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070483 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (MUTUAL PHARM) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070855 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070856 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070994 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1986
NDA 070995 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1986
NDA 071019 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 071366 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 071367 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 070577 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070737 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 070738 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 070739 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070740 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071423 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071424 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071489 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071880 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (HERITAGE PHARMS INC) APPROVAL= AP YEAR= 1988 OBSOLETE
NDA 071881 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (HERITAGE) APPROVAL= AP YEAR= 1988
NDA 071482 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 1989 OBSOLETE
NDA 071483 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072124 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (PLIVA) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072125 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (PLIVA) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 019614 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERELAN (AZURITY) APPROVAL= AP YEAR= 1990
NDA 073168 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 073568 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 072233 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (MARSAM PHARMS LLC) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 072923 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 072924 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1993
NDA 073485 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (MARSAM PHARMS LLC) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 074330 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 072888 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (BEDFORD) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 020552 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) COVERA-HS (PFIZER) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 020591 (pdf not found) INN (TRANDOLAPRIL ; VERAPAMIL HYDROCHLORIDE) TARKA (ABBVIE) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 072751 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (PLIVA) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 072922 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (PLIVA) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074587 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 020943 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERELAN PM (AZURITY) APPROVAL= AP YEAR= 1998
NDA 075136 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1998
NDA 075072 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 1999
NDA 075138 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 1999
NDA 078306 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078906 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2009
NDA 079135 (pdf not found) INN (TRANDOLAPRIL ; VERAPAMIL HYDROCHLORIDE) TRANDOLAPRIL AND VERAPAMIL HYDROCHLORIDE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2010
NDA 090529 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090700 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2011
NDA 200878 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (APOTEX CORP) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 206173 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (CADILA PHARMS LTD) APPROVAL= AP YEAR= 2017
NDA 210994 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (AMNEAL) APPROVAL= AP YEAR= 2018
NDA 211015 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2018
NDA 211035 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (SOMERSET) APPROVAL= AP YEAR= 2018
NDA 211370 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (MICRO LABS) APPROVAL= AP YEAR= 2018
NDA 212965 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2020
NDA 213232 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (CAPLIN) APPROVAL= AP YEAR= 2020
NDA 213352 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (NEPHRON) APPROVAL= AP YEAR= 2020
NDA 214215 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2020
NDA 214361 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (GLAND) APPROVAL= AP YEAR= 2020
NDA 214653 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (MANKIND PHARMA) APPROVAL= AP YEAR= 2022
NDA 215829 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (HERITAGE) APPROVAL= AP YEAR= 2022
NDA 216471 (pdf not found) INN (VERAPAMIL HYDROCHLORIDE) VERAPAMIL HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2024

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL