e-Drug3D

504

cas 62571-86-2

CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE
ANGIOTENSIN-CONVERTING ENZYME INHIBITORS

ROUTE (list)

ORAL

PK parameters

F 75 PERCENT
Tmax 1 HOUR
VD 48.7 LITER (65 KILOGRAM)
Cl 46.8 LITER / HOUR (65 KILOGRAM)
PPB 27 PERCENT
t1/2 2 HOUR

TARGET ANGIOTENSIN-CONVERTING ENZYME (ACE)

PDB
1UZF (COMPLEX OF THE ANTI-HYPERTENSIVE DRUG CAPTOPRIL AN THE HUMAN TESTICULAR ANGIOTENSIN I-CONVERTING ENZYME)

Ligand code = MCO (link to the list of PDB complexes)

Download experimental 3D coordinates of MCO with added hydrogens

MW 216.28
NB_atoms 14
XLogP -0.71
PSA 53.048
NB_HD 0
NB_HA 4
fsp3 0.78
Lipinski(0=no;1=yes) 1

FDA
NDA 074640 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018343 (label) INN (CAPTOPRIL) CAPOTEN (STRIDES PHARMA) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 018709 (pdf not found) INN (CAPTOPRIL ; HYDROCHLOROTHIAZIDE) CAPOZIDE 25/15 (APOTHECON) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 074363 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (CHARTWELL RX) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074472 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (APOTHECON) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074322 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (TEVA) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074386 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (WATSON LABS) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074418 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (OXFORD PHARMS) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074423 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (DAVA PHARMS INC) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074433 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (COSETTE) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074434 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074451 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (WATSON LABS) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074462 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (COSETTE) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074477 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (PRINSTON INC) APPROVAL= AP YEAR= 1996
NDA 074481 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (SANDOZ) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074483 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (COSETTE) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074493 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (STRIDES PHARMA) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074505 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 1996
NDA 074519 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (CHARTWELL RX) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074576 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (WATSON LABS) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074590 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (G AND W LABS INC) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074532 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (WOCKHARDT BIO AG) APPROVAL= AP YEAR= 1997
NDA 074677 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (ANDAS 5 HOLDING) APPROVAL= AP YEAR= 1997
NDA 074748 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (EGIS PHARMS) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074788 (pdf not found) INN (CAPTOPRIL ; HYDROCHLOROTHIAZIDE) CAPTOPRIL AND HYDROCHLOROTHIAZIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074827 (pdf not found) INN (CAPTOPRIL ; HYDROCHLOROTHIAZIDE) CAPTOPRIL AND HYDROCHLOROTHIAZIDE (COSETTE) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074832 (pdf not found) INN (CAPTOPRIL ; HYDROCHLOROTHIAZIDE) CAPTOPRIL AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074896 (pdf not found) INN (CAPTOPRIL ; HYDROCHLOROTHIAZIDE) CAPTOPRIL AND HYDROCHLOROTHIAZIDE (RISING) APPROVAL= AP YEAR= 1997
NDA 074737 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (COREPHARMA) APPROVAL= AP YEAR= 1998
NDA 075055 (pdf not found) INN (CAPTOPRIL ; HYDROCHLOROTHIAZIDE) CAPTOPRIL AND HYDROCHLOROTHIAZIDE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 212223 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (SETON PHARMS) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 212809 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2019
NDA 214442 (pdf not found) INN (CAPTOPRIL) CAPTOPRIL (AIPING PHARM INC) APPROVAL= AP YEAR= 2023