e-Drug3D

503

TRIFLURIDINE

INN
TRIFLURIDINE

cas 70-00-8

CLASS

SENSORY
ANTIVIRAL
ANTIMETABOLITES
TOPICAL TREATMENT OF EPITHELIAL KERATITIS CAUSED BY HERPES SIMPLEX VIRUS
INTERFER WITH DNA SYNTHESIS
IS SEQUENTIALLY PHOSPHORYLATED AND NOT ONLY INHIBITS THYMIDYLATE SYNTHASE ACTIVITY BUT IS ALSO INCORPORATED INTO DNA

ROUTE (list)

OPHTHALMIC ORAL

ATC code

S01AD02
L01BC59

PK parameters

Target

TARGET DNA

DrugCentral

Unknown

Download SDF file

1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)pyrimidine-2,4-dione

Formula:
C10H11F3N2O5

Calculated chemical properties:

MW 296.21
NB_atoms 20
XLogP -0.80
PSA 99.102
NB_HD 3
NB_HA 7
fsp3 0.60
Lipinski(0=no;1=yes) 1

FDA
NDA 018299 (pdf not found) INN (TRIFLURIDINE) VIROPTIC (MONARCH PHARMS) APPROVAL= AP YEAR= 1980 NEWMOLECULARENTITY
NDA 074311 (pdf not found) INN (TRIFLURIDINE) TRIFLURIDINE (SANDOZ) APPROVAL= AP YEAR= 1995
NDA 207981 (label) INN (TIPIRACIL HYDROCHLORIDE ; TRIFLURIDINE) LONSURF (TAIHO ONCOLOGY) APPROVAL= AP YEAR= 2015
NDA 205438 (pdf not found) INN (TRIFLURIDINE) TRIFLURIDINE (HIKMA) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 214036 (pdf not found) INN (TRIFLURIDINE ; TIPIRACIL) TRIFLURIDINE; TIPIRACIL (INTAS PHARMS LTD) APPROVAL= TA YEAR= 2022
NDA 214008 (pdf not found) INN (TIPIRACIL HYDROCHLORIDE ; TRIFLURIDINE) TIPIRACIL HYDROCHLORIDE AND TRIFLURIDINE (NATCO) APPROVAL= AP YEAR= 2023
NDA 214024 (pdf not found) INN (TIPIRACIL HYDROCHLORIDE ; TRIFLURIDINE) TIPIRACIL HYDROCHLORIDE AND TRIFLURIDINE (MSN) APPROVAL= AP YEAR= 2025