e-Drug3D

501

cas 28981-97-7

CLASS

NERVOUS SYSTEM
ANXIOLYTIC
ANTI-ANXIETY AGENTS
BENZODIAZEPINES
GABA MODULATORS
HYPNOTICS AND SEDATIVES

ROUTE (list)

ORAL

PK parameters

F 90 PERCENT
Tmax 1.5 HOUR
VD 52 LITER (65 KILOGRAM)
Cl 2.88 LITER / HOUR (65 KILOGRAM)
PPB 80 PERCENT
t1/2 11.2 HOUR

TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR

PDB
3U5J (CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH ALPRAZOLAM)

Ligand code = 08H (link to the list of PDB complexes)

Download experimental 3D coordinates of 08H with added hydrogens

MW 308.76
NB_atoms 22
XLogP 3.58
PSA 36.612
NB_HD 0
NB_HA 4
fsp3 0.12
Lipinski(0=no;1=yes) 1

FDA
NDA 018276 (label) INN (ALPRAZOLAM) XANAX (UPJOHN) APPROVAL= AP YEAR= 1981
NDA 074046 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (PHARMOBEDIENT) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 074174 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (NOVITIUM PHARMA) APPROVAL= AP YEAR= 1993
NDA 074199 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (ROXANE) APPROVAL= TA YEAR= 1993
NDA 074312 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (HIKMA) APPROVAL= AP YEAR= 1993
NDA 074314 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (ROXANE) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 074342 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1993
NDA 074085 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (ANI PHARMS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074215 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (MYLAN) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074294 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074112 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (SANDOZ) APPROVAL= AP YEAR= 1995
NDA 074456 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (WATSON LABS) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074479 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (WATSON LABS) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074909 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (SANDOZ) APPROVAL= AP YEAR= 1998
NDA 021434 (label) INN (ALPRAZOLAM) XANAX XR (UPJOHN) APPROVAL= AP YEAR= 2003
NDA 021726 (label) INN (ALPRAZOLAM) NIRAVAM (UCB INC) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077391 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (PHARMOBEDIENT) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077725 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (ANI PHARMS) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077777 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (SANDOZ INC) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077741 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (APOTEX INC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077968 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (IMPAX LABS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077979 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (ANI PHARMS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077996 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (IMPAX LABS INC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078056 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2007
NDA 078442 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (PH HEALTH) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078387 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (AMNEAL PHARMS NY) APPROVAL= AP YEAR= 2008
NDA 078449 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (APOTEX INC) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078489 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (HERITAGE PHARMS INC) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078491 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (OXFORD PHARMS) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078088 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (PH HEALTH) APPROVAL= AP YEAR= 2009
NDA 078561 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2010
NDA 077198 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090082 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (SUN PHARM) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090248 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (STRIDES PHARMA) APPROVAL= AP YEAR= 2010
NDA 090871 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2011
NDA 078469 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (PH HEALTH) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 200739 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (NATCO) APPROVAL= AP YEAR= 2015
NDA 203346 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2015
NDA 207507 (pdf not found) INN (ALPRAZOLAM) ALPRAZOLAM (CHARTWELL RX) APPROVAL= AP YEAR= 2018