e-Drug3D

50

cas 76-99-3

CLASS

NERVOUS SYSTEM
ANALGESIC OPIOID
ANTITUSSIVE AGENTS
ANTITUSSIVES NARCOTICS
OPIOID RECEPTOR AGONISTS
TREATMENT OF OPIOID ADDICTION
NMDA ANTAGONIST

ROUTE (list)

ORAL INJECTION

PK parameters

F 68 PERCENT
VD 286 LITER (65 KILOGRAM)
Cl 6.6 LITER / HOUR (65 KILOGRAM)
PPB 79 PERCENT
t1/2 31 HOUR

MW 309.44
NB_atoms 23
XLogP 4.29
PSA 17.811
NB_HD 0
NB_HA 2
fsp3 0.38
Lipinski(0=no;1=yes) 1

FDA
NDA 006134 (pdf not found) INN (METHADONE HYDROCHLORIDE) DOLOPHINE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 1947 DISCONTINUED
NDA 006383 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (MALLINCKRODT INC) APPROVAL= AP YEAR= 1947 DISCONTINUED
NDA 021624 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (MYLAN INSTITUTIONAL) APPROVAL= AP YEAR= 1947
NDA 017058 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 1973
NDA 017108 (pdf not found) INN (METHADONE HYDROCHLORIDE) WESTADONE (SANDOZ) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 017116 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADOSE (SPECGX LLC) APPROVAL= AP YEAR= 1973
NDA 087393 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 1981
NDA 087997 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 1982
NDA 088108 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (ROXANE) APPROVAL= AP YEAR= 1983 OBSOLETE
NDA 088109 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 1983
NDA 089897 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE INTENSOL (HIKMA) APPROVAL= AP YEAR= 1988
NDA 040050 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADOSE (SPECGX LLC) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 074184 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADOSE (SPECGX LLC) APPROVAL= AP YEAR= 1993
NDA 040088 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (VISTAPHARM LLC) APPROVAL= AP YEAR= 1994
NDA 074081 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (ROXANE) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 040180 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 1998
NDA 040241 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (VISTAPHARM LLC) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 075082 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (VISTAPHARM LLC) APPROVAL= AP YEAR= 1998
NDA 040517 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (SPECGX LLC) APPROVAL= AP YEAR= 2004
NDA 077142 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (SPECGX LLC) APPROVAL= AP YEAR= 2005
NDA 090635 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (THEPHARMANETWORK LLC) APPROVAL= AP YEAR= 2009
NDA 090707 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (VISTAPHARM LLC) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090065 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2015
NDA 203502 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (AUROLIFE PHARMA LLC) APPROVAL= AP YEAR= 2015
NDA 208306 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (LONG GROVE PHARMS) APPROVAL= AP YEAR= 2017
NDA 208305 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 210484 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (ELITE LABS INC) APPROVAL= AP YEAR= 2018
NDA 211228 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (ASCENT PHARMS INC) APPROVAL= AP YEAR= 2019
NDA 207368 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (SPECGX LLC) APPROVAL= AP YEAR= 2019
NDA 207537 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (SPECGX LLC) APPROVAL= AP YEAR= 2019
NDA 204166 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (VISTAPHARM LLC) APPROVAL= AP YEAR= 2020
NDA 212093 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (LANNETT CO INC) APPROVAL= AP YEAR= 2020
NDA 212094 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (LANNETT CO INC) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 218252 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (BRECKENRIDGE) APPROVAL= AP YEAR= 2024
NDA 218609 (pdf not found) INN (METHADONE HYDROCHLORIDE) METHADONE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2025