e-Drug3D

498

DIPIVEFRIN

DISCONTINUED

INN
DIPIVEFRIN

(has an active metabolite)

cas 52365-63-6

CLASS

SENSORY
ADRENERGIC AGONISTS
SYMPATHOMIMETICS
CONTROL OF INTRAOCULAR PRESSURE IN CHRONIC OPEN-ANGLE GLAUCOMA

ROUTE (list)

OPHTHALMIC

ATC code

S01EA02

PK parameters

Solubility

FREELY SOLUBLE IN WATER

Target

TARGET ALPHA-2A ADRENERGIC RECEPTOR

DrugCentral

Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A

Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B

Alpha-2C adrenergic receptor UNIPROT P18825 ADRA2C

Download SDF file

[2-(2,2-dimethylpropanoyloxy)-5-(1-hydroxy-2-methylaminoethyl)phenyl] 2,2-dimethylpropanoate

Formula:
C19H29NO5

Calculated chemical properties:

MW 351.43
NB_atoms 25
XLogP 2.84
PSA 78.136
NB_HD 2
NB_HA 6
fsp3 0.58
Lipinski(0=no;1=yes) 1

FDA
NDA 018239 (label) INN (DIPIVEFRIN HYDROCHLORIDE) PROPINE (ALLERGAN) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 073636 (pdf not found) INN (DIPIVEFRIN HYDROCHLORIDE) DIPIVEFRIN HYDROCHLORIDE (FALCON PHARMS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074188 (pdf not found) INN (DIPIVEFRIN HYDROCHLORIDE) DIPIVEFRIN HYDROCHLORIDE (BAUSCH AND LOMB) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074382 (pdf not found) INN (DIPIVEFRIN HYDROCHLORIDE) AKPRO (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1995 DISCONTINUED