e-Drug3D

497

cas 33125-97-2

CLASS

NERVOUS SYSTEM
HYPNOTIC
ANXIOLYTIC
SEDATIVES

ROUTE (list)

INJECTION

PK parameters

VD 175.5 LITER (65 KILOGRAM)
Cl 50.7 LITER / HOUR (65 KILOGRAM)
PPB 76 PERCENT
t1/2 1.25 HOUR

TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR

PDB
6X3V (HUMAN GABAA RECEPTOR ALPHA1-BETA2-GAMMA2 SUBTYPE IN COMPLEX WITH GABA PLUS ETOMIDATE)

Ligand code = V8D (link to the list of PDB complexes)

Download experimental 3D coordinates of V8D with added hydrogens

MW 244.29
NB_atoms 18
XLogP 2.67
PSA 38.059
NB_HD 0
NB_HA 4
fsp3 0.29
Lipinski(0=no;1=yes) 1

FDA
NDA 018227 (pdf not found) INN (ETOMIDATE) AMIDATE (HOSPIRA) APPROVAL= AP YEAR= 1982
NDA 074593 (pdf not found) INN (ETOMIDATE) ETOMIDATE (HIKMA) APPROVAL= AP YEAR= 1996
NDA 078289 (pdf not found) INN (ETOMIDATE) ETOMIDATE (RISING) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 078867 (pdf not found) INN (ETOMIDATE) ETOMIDATE (LUITPOLD) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 091297 (pdf not found) INN (ETOMIDATE) ETOMIDATE (PH HEALTH) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202360 (pdf not found) INN (ETOMIDATE) ETOMIDATE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2014
NDA 204618 (pdf not found) INN (ETOMIDATE) ETOMIDATE (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 202354 (pdf not found) INN (ETOMIDATE) ETOMIDATE (HIKMA) APPROVAL= AP YEAR= 2016
NDA 201044 (pdf not found) INN (ETOMIDATE) ETOMIDATE (MYLAN LABS LTD) APPROVAL= AP YEAR= 2017
NDA 206126 (pdf not found) INN (ETOMIDATE) ETOMIDATE (EUGIA PHARMA) APPROVAL= AP YEAR= 2017
NDA 209058 (pdf not found) INN (ETOMIDATE) ETOMIDATE (GLAND) APPROVAL= AP YEAR= 2017
NDA 215028 (pdf not found) INN (ETOMIDATE) ETOMIDATE (CAPLIN) APPROVAL= AP YEAR= 2020