e-Drug3D

496

cas 28395-03-1

CLASS

CARDIOVASCULAR
DIURETIC
NA(+)-K(+)-2CL(-) COTRANSPORTER ISOFORM 1 INHIBITOR (PMID23788048)

ROUTE (list)

ORAL INJECTION

PK parameters

Tmax 1.5 HOUR
VD 10.4 LITER (65 KILOGRAM)
Cl 11.3 LITER / HOUR (65 KILOGRAM)
PPB 95 PERCENT
t1/2 1.25 HOUR

TARGET SODIUM POTASSIUM CHLORIDE COTRANSPORTER (NKCC1)

PDB
7S1Y (CRYO-EM STRUCTURE OF HUMAN NKCC1 K289NA492E BOUND WITH BUMETANIDE)

Ligand code = 82U (link to the list of PDB complexes)

Download experimental 3D coordinates of 82U with added hydrogens

MW 363.41
NB_atoms 25
XLogP 1.70
PSA 114.059
NB_HD 3
NB_HA 7
fsp3 0.24
Lipinski(0=no;1=yes) 1

FDA
NDA 018225 (label) INN (BUMETANIDE) BUMEX (VALIDUS PHARMS) APPROVAL= AP YEAR= 1983
NDA 018226 (label) INN (BUMETANIDE) BUMEX (VALIDUS PHARMS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 074332 (pdf not found) INN (BUMETANIDE) BUMETANIDE (HOSPIRA) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074225 (pdf not found) INN (BUMETANIDE) BUMETANIDE (HERITAGE PHARMA) APPROVAL= AP YEAR= 1995
NDA 074441 (pdf not found) INN (BUMETANIDE) BUMETANIDE (SAGENT) APPROVAL= AP YEAR= 1995
NDA 074700 (pdf not found) INN (BUMETANIDE) BUMETANIDE (SANDOZ) APPROVAL= AP YEAR= 1996
NDA 074160 (pdf not found) INN (BUMETANIDE) BUMETANIDE (HOSPIRA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074613 (pdf not found) INN (BUMETANIDE) BUMETANIDE (TEVA PARENTERAL) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 079196 (pdf not found) INN (BUMETANIDE) BUMETANIDE (WEST-WARD PHARMS INT) APPROVAL= AP YEAR= 2008
NDA 209724 (pdf not found) INN (BUMETANIDE) BUMETANIDE (AMNEAL PHARMS CO) APPROVAL= AP YEAR= 2017
NDA 202900 (pdf not found) INN (BUMETANIDE) BUMETANIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2018
NDA 209916 (pdf not found) INN (BUMETANIDE) BUMETANIDE (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2018
NDA 212019 (pdf not found) INN (BUMETANIDE) BUMETANIDE (RISING) APPROVAL= AP YEAR= 2019
NDA 216434 (pdf not found) INN (BUMETANIDE) BUMETANIDE (GLAND) APPROVAL= AP YEAR= 2022
NDA 215364 (pdf not found) INN (BUMETANIDE) BUMETANIDE (MSN) APPROVAL= AP YEAR= 2022
NDA 213458 (pdf not found) INN (BUMETANIDE) BUMETANIDE (TARO) APPROVAL= AP YEAR= 2023
NDA 212931 (pdf not found) INN (BUMETANIDE) BUMETANIDE (APPCO) APPROVAL= AP YEAR= 2024
NDA 213942 (pdf not found) INN (BUMETANIDE) BUMETANIDE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2024
NDA 217153 (pdf not found) INN (BUMETANIDE) BUMETANIDE (LUPIN LTD) APPROVAL= AP YEAR= 2024
NDA 219116 (pdf not found) INN (BUMETANIDE) BUMETANIDE (QILU PHARM HAINAN) APPROVAL= AP YEAR= 2024
NDA 212470 (pdf not found) INN (BUMETANIDE) BUMETANIDE (JUBILANT GENERICS) APPROVAL= AP YEAR= 2025
NDA 218746 (pdf not found) INN (BUMETANIDE) BUMETANIDE (ASPIRO) APPROVAL= AP YEAR= 2025
NDA 219291 (pdf not found) INN (BUMETANIDE) BUMETANIDE (MANKIND PHARMA) APPROVAL= AP YEAR= 2025